2014
DOI: 10.1016/bs.apcsb.2014.06.006
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Stability of Amyloid Oligomers

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Cited by 23 publications
(25 citation statements)
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References 183 publications
(213 reference statements)
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“…The strong interest in oligomeric species is also supported by the need for new therapeutic or diagnostic targets.Alarge number of reviews on amyloid oligomers have recently been published. [12][13][14][15][16][17][18][19][20] They focus either on single proteins or peptides as associated with one type of disease or on differenta spects of the oligomeric structures in the context of amyloid formation in general. Of special interest, for instance, is the impact of bound metal ions on the self-assembly of amyloid proteins.…”
Section: Introductionmentioning
confidence: 99%
“…The strong interest in oligomeric species is also supported by the need for new therapeutic or diagnostic targets.Alarge number of reviews on amyloid oligomers have recently been published. [12][13][14][15][16][17][18][19][20] They focus either on single proteins or peptides as associated with one type of disease or on differenta spects of the oligomeric structures in the context of amyloid formation in general. Of special interest, for instance, is the impact of bound metal ions on the self-assembly of amyloid proteins.…”
Section: Introductionmentioning
confidence: 99%
“…The later suffer from the problem that aggregation, and conversions between different forms of aggregates, takes hours or longer, that is happens on time scales that are not accessible in molecular dynamic simulations. 5,6 For this reason, we address the above question by comparing the stability of structurally distinct Ab amyloid fibrils in atomistic molecular dynamics simulations with explicit solvent. Specifically, we study a two-fold in vitro model of Ab fibrils (PDB code: 2LMO), a three-fold in vitro model (PDB code: 2LMP), and the three-fold in vivo (patient-derived) model (PDB code: 2M4J).…”
Section: Introductionmentioning
confidence: 99%
“…While faster than direct aggregation simulations, such stability investigations are still computationally taxing, and often the temperature is raised to increase sampling speed. 5,7 In the present paper, we use a different approach, reducing the viscosity of the system through mass scaling. Long-time all-atom explicit solvent molecular simulations are performed of in vitro and in vivo Ab fibril models of various arrangements and sizes.…”
Section: Introductionmentioning
confidence: 99%
“…Manipulation of aoTTR resulted in the emergence of intermediates whose mechanical transitions occurred at higher force values than those observed in nTTR (Figure D). This difference could be interpreted because of amyloid oligomers typically attain a more stable state than the native protein from which they are derived . However, such interpretation should be viewed with some caution.…”
Section: Discussionmentioning
confidence: 99%
“…This difference could be interpreted because of amyloid oligomers typically attain a more stable state than the native protein from which they are derived. [53][54][55][56][57][58][59][60][61] However, such interpretation should be viewed with some caution.…”
Section: Unfolding Force Of Intermediatesmentioning
confidence: 99%