Stability of admixtures of pethidine and metoclopramide in aqueous solution, 5% dextrose and 0.9% sodium chloride

Abstract

All preparations were found to be physically and chemically stable for at least 48h, as concentration changes were within 10% of their initial level, with no development of haze, precipitate or colour. Light appeared to have a negligible effect. Although pH changes were observed, they were inconsistent and were within the ranges in which the drugs are expected to remain stable. Pethidine and metoclopramide admixtures can, therefore, on stability grounds be used for the concomitant management of pain, nausea and vomiting.

The current evidence base for the feasibility of 48-hour continuous subcutaneous infusions (CSCIs): A systematically-structured review

“…Eighteen of the included studies investigated compatibility at ambient temperature (18–25°C)[ 13 – 21 , 25 – 29 , 31 – 34 ], eleven also investigated compatibility at refrigerated temperature (4–8°C)[ 15 , 18 – 21 , 25 – 28 , 31 , 32 ], five investigated at body temperature (36–38°C)[ 13 , 15 , 25 , 32 , 35 ] and two studies investigated compatibility at 32°C, simulating a syringe held in a sling close to the patients’ body[ 24 , 30 ].…”

“…A total of 24 drugs were included in the 21 studies, involving 32 different combinations. The most drugs included in a single combination were six[ 26 ] and the least included in a single combination were two[ 13 , 15 – 21 , 23 , 24 , 28 , 29 , 32 – 34 ]. The drugs included most frequently in syringe driver combinations reported were haloperidol ( n = 13), morphine sulphate, midazolam and dexamethasone ( n = 7 each).…”