Stability of a pyrimethamine suspension compounded from bulk powder

Abstract

The study demonstrated that USP-grade pyrimethamine powder can be formulated as a 2-mg/mL suspension in a vehicle of Ora-Plus and Ora-Sweet and is stable when stored at room temperature and when refrigerated, in amber plastic bottles, for 48 and 90 days, respectively.

Successful Treatment of Cerebral Toxoplasmosis Using Pyrimethamine Oral Solution Compounded From Inexpensive Bulk Powder

“…The stability of pyrimethamine compounded into a liquid dosage formulation has been demonstrated out to 91 days [ 10 ]; however, this method used crushed pyrimethamine tablets. Lewis et al were the first to investigate the stability of pyrimethamine oral suspension compounded from a USP grade bulk powder (Medisca Pharmaceuticals) [ 11 ]. A stability-indicating high-performance liquid chromatographic (HPLC) method with ultraviolet (UV) detection was performed to determine the beyond-use date of the oral suspension compounded from this bulk pyrimethamine powder.…”