Stability-Indicating LC Determination of a New Antihypertensive, Olmesartan Medoxomil in Tablets

Bajerski, Lisiane; Rossi, Rochele Cassanta; Dias, Carolina Lupi; Bergold, Ana María; Fröehlich, Pedro Eduardo

doi:10.1365/s10337-008-0811-3

Cited by 23 publications

(19 citation statements)

References 8 publications

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“…It has many applications in the field of pharmaceuticals including the quantitative determination of drugs present either alone or in presence of their degradation [9–12]. …”

Section: Resultsmentioning

confidence: 99%

Different Stability-Indicating Chromatographic Techniques for the Determination of Netobimin

Ramadan

Mohamed²,

Shawky³

et al. 2012

Journal of Analytical Methods in Chemistry

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Two simple, accurate, and sensitive methods were developed for the determination of netobimin in the presence of its degradation product. Method (A) was an HPLC method, performed on C18 column using acetonitrile/methanol/0.01 M potassium dihydrogen phosphate (56 : 14 : 30 by volume) as a mobile phase with a flow rate of 0.5 mL/min. Detection was performed at 254 nm. Method (B) was a TLC method, using silica gel 60 F254 plates; the optimized mobile phase was toluene/methanol/chloroform/ammonium hydroxide (5 : 4 : 6 : 0.1 by volume). The spots were scanned densitometrically at 346 nm. Linearity ranges were 1–10 μg/mL for method (A) and 0.5–5 μg/band for method (B), and the mean percentage recoveries were 99.3 ± 0.7% and 99.7 ± 0.7% for methods (A) and (B), respectively. The proposed methods were found to be specific for netobimin in the presence of up to 90% of its degradation product. Statistical comparison between the results obtained by these methods and the manufacturer method was done, and no significance difference was obtained.

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“…It has many applications in the field of pharmaceuticals including the quantitative determination of drugs present either alone or in presence of their degradation [9–12]. …”

Section: Resultsmentioning

confidence: 99%

Different Stability-Indicating Chromatographic Techniques for the Determination of Netobimin

Ramadan

Mohamed²,

Shawky³

et al. 2012

Journal of Analytical Methods in Chemistry

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“…Excipient concentration in this dosage form was based on the literature 24,25 and calculated in relation to medium weight. The electropherograms of excipient placebo solution (without drugs), OLM RS and DICL IS solutions were compared to verify the probable interference of the excipients on OLM quantitation.…”

Section: Specificitymentioning

confidence: 99%

Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil

et al. 2013

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Recebido em 24/2/12; aceito em 25/7/12; publicado na web em 11/12/12 A stability-indicating method using MEKC was validated for the analysis of olmesartan medoxomil in tablets. Successful separation was achieved using a fused silica capillary (40 cm x 50 μm i.d.); background electrolyte consisted of a combination of 10 mmol L -1 borate buffer and 5 mmol L -1 anionic detergent sodium dodecyl sulfate (95:5; v/v) pH 6.5; hydrodynamic mode at 50 mBar for 5 s; 25 kV separation voltage at 25 °C; and column temperature 25 °C with detection at 257 nm. The proposed method, validated following ICH guidelines, was applied to the determination of this antihypertensive with good results compared with an LC method.

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“…The present study compares LC determination of olmesartan by identification and characterizing the impurity of olmesartan medoxomil [11][12] .…”

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confidence: 99%

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IJPSR

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Stability-Indicating LC Determination of a New Antihypertensive, Olmesartan Medoxomil in Tablets

Cited by 23 publications

References 8 publications

Different Stability-Indicating Chromatographic Techniques for the Determination of Netobimin

Different Stability-Indicating Chromatographic Techniques for the Determination of Netobimin

Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil

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