Stability Indicating HPTLC and LC Determination of Dasatinib in Pharmaceutical Dosage Form

Analysis of anticancer drugs using thin layer chromatography- A review

“…After the treatment of acid, base, oxidation and heat; the drug undergoes degradation under all these conditions [17]. The stability indicating HPTLC methods of dasatinib, irinotecan, gemcitabine HCl, anastrozole and leuprolide acetate were also reported [18][19][20][21][22].…”

“…Most of the published method development studies include stability indicating HPTLC of the anticancer agents in bulk drug and pharmaceuticals [17][18][19][20][21][22]. In one of these methods, Vadera et al developed a stability indicating HPTLC method for the determination of imatinib mesylate as a bulk drug and in pharmaceuticals.…”

Review on Analytical Method Development and Validation by HPLC/Lc-MS of Selected Anti-Cancer Drugs

“…The method was stastically validated according with FDA for linearity,accuracy,precision,selectivity and stability.The assay linear range of 50.0-3000ng/ml with LOD of 15.0ng/ml, accuracy of dasatinib was within ±15% of theoretical value.The assay of dasatinib is applied to pharmacokinetic study. [25] : Introduced a stability indicating HPTLC and LC estimation of dasatinib in pharmaceutical dosage form this method is very sensitive,accurate for quantitative determination of dasatinib in the prescence of degradation products. The frist method high performance thinlayer liquid chromatography used by densitometric measurement and second method is based on RP-HPLC using C18 column and this both method validated according with ICH guidelines,this method is effectively separate the drug from its degradation products and it is employed as stability indicating methods subjected to acid,alkali hydrolysis,oxidation,dry heat,photo-degradation.…”

Development and validation of a HPTLC method for analysis of Sunitinib malate

“…In recent years, numerous publications have been devoted to the application of HPTLC methods in pharmaceutical analysis (Sherma, 2010;Askal et al, 2008;Kadam, Bari, 2007;Mhaske, Dhaneshwar, 2007). For example, the following cases can be mentioned: determination of amantadine, an antiviral drug, in pharmaceu tical formulations (Askal et al, 2008), simultaneous analysis of valsartan and hydrochlorothiazide, an antihypertensive drug, in tablet formulation (Kadam, Bari, 2007), determination of omeprazole, a proton pump inhibitor, in capsule form (Jha et al, 2010), simultaneous quantitation of paracetamol, diclofenac potassium, and famotidine in tablet formulation (Khatal et al, 2010), determination of imatinib (Vadera, Subramanian, Musmade, 2007) and dasatinib (Mhaske, Dhaneshwar, 2007) as anticancer medicines in pharmaceutical form.…”