Stability and thermosensitive properties of various poly ( N -vinylcaprolactam) microgels

Cytotoxicity of thermosensitive polymers poly(N-isopropylacrylamide), poly(N-vinylcaprolactam) and amphiphilically modified poly(N-vinylcaprolactam)

“…This diminishes the ability of the amphiphilic PEO-macromonomer to adsorb to the cellular surface and the steric repulsion caused by PEO is effective. The high stabilization ability of MAC 11 EO 42 graft was previously observed also for grafted microgels; the grafted particles did not aggregate because of the strong steric repulsion generated by the graft [42]. By increasing the hydrophilicity of the polymer, it has been found possible to enhance biocompatibility [17].…”

Poly(N-vinylcaprolactam), a comprehensive review on a thermoresponsive polymer becoming popular

“…It can be performed in the A variety of comonomers have been used in the preparation of micro-/nanogels of PNVCL (see Fig. 14): thermoresponsive as NIPAAm [157,173] and NIPMAAm [173] with reactive groups as glycidyl methacrylate [160,172,174], hydrophopic as acetoacetoxyethyl methacrylate (AAEM) [160][161][162][163][164][167][168][169], vinyl acetate [175], itaconic acid dimethyl ester (IADME) [176], and methyl methacrylate [48]; ionic comonomers such as the weak acids: acrylic acid [177], methacrylic acid [161,178], acrylamidoglycolic acid (AGA) [179], and sodium acrylate [180][181][182][183]; weak bases like vinylimidazole [176,184,185] and N,N'-dimethylaminoethylmethacrylate [186]; strong bases like 4-vinylpyridine (4VP) [187]; hydrophilic as N-vinylpyrrolidone [188,189], 3- [47,190], vinyl alcohol [191], vinyl-β-cyclodextrins (V-β-CD) and other cyclodextrins [192], and poly(ethylene glycol) methyl ether methacrylate (PEGMA) [155,178,[193][194]…”

Thermosensitive graft copolymers of an amphiphilic macromonomer and N-vinylcaprolactam: synthesis and solution properties in dilute aqueous solutions below and above the LCST

“…It has been shown that PVCL forms nano-sized aggregates when the solution is heated above the cloud point [19]. It was therefore expected that introduction of amphiphilic grafts on a polymer chain will modify the structure of these heat-induced aggregates, and possibly stabilize them against flocculation, as in the case of sterically stabilised latexes [16]. The surface of the aggregates is covered with highly hydrophilic PEO chains, which further stabilise the particles.…”

“…Amphiphilic poly(ethylene oxide) macromonomers have been used also as reactive surfactants in emulsion [11,12] and dispersion [13][14][15] polymerisations to produce stable polymer particles, latexes. The steric stabilisation created by the non-ionic amphiphilic grafts is a way to prepare particles that have a pronounced stability against aggregation even at high electrolyte concentration [16] or after a freeze-thaw cycle [17].…”