Stability and refolding of Dihydrofolate reductase enhances with nano-conjugation

Verma, Ritu; Singh, Neetu; Chaudhuri, Pratima

doi:10.1016/j.ijbiomac.2020.11.053

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Conjugation is a concept widely used in various disciplines including mathematics, physics, chemistry, and other fields. − It refers to a pair of subjects that mirror each other based on a certain rule. Conjugation is generally found to stabilize various systems. , It has been reported that adding m -xylene diamine into polyimine vitrimers can greatly improve its thermal stability due to the extended conjugated structure .…”

Section: Introductionmentioning

confidence: 99%

“…Conjugation is generally found to stabilize various systems. , It has been reported that adding m -xylene diamine into polyimine vitrimers can greatly improve its thermal stability due to the extended conjugated structure . The thermal stability of zDHFR protein can be improved by constructing nanoconjugation structures . In the field of electrochemical energy storage, indole-based conjugated macromolecules and CNTs–PANI–PEDOT materials with conjugated structures have been found to have improved stability upon cycling. , In this regard, exploring the viability of using conjugated structures at the device level to suppress the self-discharge of supercapacitors has both scientific and technological significance. , …”

Section: Introductionmentioning

confidence: 99%

“…56 The thermal stability of zDHFR protein can be improved by constructing nanoconjugation structures. 55 In the field of electrochemical energy storage, indole-based conjugated macromolecules and CNTs−PANI−PEDOT materials with conjugated structures have been found to have improved stability upon cycling. 58,60 In this regard, exploring the viability of using conjugated structures at the device level to suppress the self-discharge of supercapacitors has both scientific and technological significance.…”

Section: Introductionmentioning

confidence: 99%

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A Conjugately Configured Supercapacitor with Suppressed Self-Discharge by Coupling Pairs of Presodiated Manganese Oxides

et al. 2022

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The wider application of conventional electrochemical double-layer supercapacitors is limited by severe self-discharge. Current strategies for tackling self-discharge are mainly focused on each specific component of the device, while a general approach based on configuration design from the device level is largely unknown. Herein, we report a conjugated supercapacitor based on pairs of presodiated manganese oxides with the unique working mechanism of redox pseudocapacitance. Upon aging, the holding time for voltage dropping from 1.0 to 0.4 V for the conjugated device based on Na x δ-MnO2 vs Na1–x δ-MnO2 is four times longer than that of an activated carbon (AC) vs AC device. The successful suppression of self-discharge based on designing device configuration is expected to be universally viable for other capacitive materials.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Conjugately Configured Supercapacitor with Suppressed Self-Discharge by Coupling Pairs of Presodiated Manganese Oxides

et al. 2022

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Conjugation to gold nanoparticles of methionine gamma-lyase, a cancer-starving enzyme. Physicochemical characterization of the nanocomplex for prospective nanomedicine applications

Raboni,

Fumagalli,

Ceccone

et al. 2024

International Journal of Pharmaceutics

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Nanoparticles Mediated Protein Stability in Comparison with Osmolytes: in vivo Approach

2021

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The native three-dimensional structure of protein is quite unstable under critical destabilizing conditions. In order to enhance the stability and activity for a proper folded environment of a protein, many stabilizing materials are added such as nanoparticles and osmolytes to an unfolded state of protein. Osmolytes are the important group of molecules which are engaged by the cell as an adaption in the severe conditions. In this communication, a comparative in vivo study is reported for imparting the status of stability and folding ability of zebrafish dihydrofolate reductase (zDHFR) protein with gold nanoparticles and various osmolytes (glycerol, glucose and betain). Present observations revealed that the interaction of gold nanoparticles (AuNPs) with bacteria at the cellular level helps in maintaining the stability of protein more effectively than osmolytes which could be used for many biological and pharmacological approaches although glycerol as an osmolyte also stabilizes the protein at a significant level.

show abstract

Stability and refolding of Dihydrofolate reductase enhances with nano-conjugation

Cited by 4 publications

References 22 publications

A Conjugately Configured Supercapacitor with Suppressed Self-Discharge by Coupling Pairs of Presodiated Manganese Oxides

A Conjugately Configured Supercapacitor with Suppressed Self-Discharge by Coupling Pairs of Presodiated Manganese Oxides

Conjugation to gold nanoparticles of methionine gamma-lyase, a cancer-starving enzyme. Physicochemical characterization of the nanocomplex for prospective nanomedicine applications

Nanoparticles Mediated Protein Stability in Comparison with Osmolytes: in vivo Approach

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