Abstract:The spatiotemporal distribution profile of polymeric nanoparticles (NPs) in the eye is important as it will determine their effectiveness as topical ocular drug delivery systems for specific eye diseases. Physical stability of the nanoparticles in an ophthalmic formulation and thermal stability of the entrapped drug are critical as well to the applicability of polymeric nanoparticles as drug delivery to the eye. To investigate these characteristics, Cy5-labeled, poly(lactic-co-glycolic acid) (PLGA) NPs (ζ-pote… Show more
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