Stability and compatibility of etoposide in 0.9% sodium chloride injection in three containers

Barthes, Damile M. C.; Rochard, E.; Pouliquen, Isabelle; Rabouan, Sylvie; Courtois, P

doi:10.1093/ajhp/51.21.2706

Cited by 7 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the 100-mg/L concentration (Table 3 ), we observed that the solution was stable for 24 h in the NaCl 0.9 % and 12 h in the D5W, both at room temperature and at 33 °C. Regarding the 400-mg/L solution, etoposide was stable for 24 h in both diluents, both at room temperature and at 33 °C (Table 4 ), which is consistent with reported data [ 3 , 5 ]. We retained a 24-h stability period for NaCl 0.9 % and D5W solutions at 400 mg/L.…”

Section: Resultssupporting

confidence: 92%

“…Stability periods of 8 and 6 h were found for NaCl 0.9 % and D5W solutions stored at room temperature and at 33 °C, respectively (Table 5 ). According to the literature [ 3 – 5 ], above 400 mg/L, etoposide concentrations decrease dramatically, with precipitate formation resulting in a 24-h stability period. In our study, the 600-mg/L solutions were found to be stable up to 8 h at room temperature and up to 6 h at 33 °C (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Neither light nor the container had an impact on solution stability [ 3 , 4 ]. However, the temperature did have an impact on the stability of the solution, since a room temperature of 20–24 °C was reportedly more suitable than a refrigerated one (4–12 °C) [ 5 , 6 ]. Etoposide stability is also concentration dependent without drug degradation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices

et al. 2014

View full text Add to dashboard Cite

In a context of day hospital care of cancer patients, a protocol combining etoposide and carboplatin is used in paediatrics. Disposable infusion devices can be used to improve patient quality of life and to optimize nursing time. Stability data are available for carboplatin in these devices but not for etoposide. The aim of this study was to determine the stability of etoposide solutions in these devices by monitoring the changing etoposide concentration. To study the changing etoposide concentration, we investigated three different concentrations, each in two different solvents: sodium chloride (NaCl) 0.9 % and dextrose 5 %, in Intermate® disposable infusion devices. Quantitative analyses were performed by high-performance liquid chromatography coupled with ultraviolet (UV) detection on samples collected over a 24-h study period. The results showed that 100 mg/L etoposide solutions were stable for 24 h in NaCl 0.9 % and for 12 h in dextrose 5 %, whatever the temperature. The 400-mg/L solutions were stable for 24 h in both diluents, whatever the temperature, whereas the 600-mg/L solutions when diluted in NaCl 0.9 % and dextrose 5 % in water were stable for 8 and 6 h, respectively. We found that precipitation was the main phenomenon responsible for decreased etoposide concentrations. This study allowed us to conclude that etoposide solutions prepared in Intermate® infusion devices are stable for day hospital administration in paediatrics. It will also allow us to conduct a future clinical study that will focus on the medico-economic feasibility of this protocol and on the evaluation of patient and nurse satisfaction.

show abstract

Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Data available about the extent of leaching of DEHP into etoposide solutions stored in PVC bags have been inconsistent (8–10). These differences could be explained by differences in PVC used by different manufacturers.…”

Section: Introductionmentioning

confidence: 99%

Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous etoposide solution

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Stability studies of 0.4 mg/mL etoposide solutions were reported in a number of previous publications. Barthes et al recommended that 0.4 mg/mL solutions of etoposide should not be stored more than 24 hours at 25°C and 2°C to 8°C 3. Joel et al determined a 7-day stability for 0.4 mg/mL etoposide solution in polyvinylchloride (PVC) bags, at 25°C in 0.9% NaCl and 5% glucose 4.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical stability of etoposide diluted at range concentrations between 0.38 and 1.75 mg/mL in polyolefin bags

D’Huart¹,

Vigneron

Lider

et al. 2018

Eur J Hosp Pharm

View full text Add to dashboard Cite

IntroductionAccording to the manufacturers, the diluted solution of etoposide should not exceed 0.4 mg/mL because precipitation may occur. For high doses or for patients requiring fluid restrictions, etoposide phosphate may be an option but shortages occurs frequently. The objective of this work was to study the stability of etoposide solutions between 0.38 and 1.75 mg/mL, diluted in 0.9% sodium chloride (0.9% NaCl) or 5% glucose (G5%) in polyolefin bags, stored at 25°C and between 2°C to 8°C, in a 61-day period. This study also observed the impact of an infusion pump on the physical and chemical stability of etoposide solutions.Materials and methodChemical stability was analysed at days 0, 9, 16, 21, 28 and 61 by high-performance liquid chromatography. Physical stability was evaluated by visual and subvisual inspection. The action of an infusion pump on solutions was evaluated to verify the impact of the mechanical pumping action on the etoposide solutions. This investigation was performed at day 61, at the end of the study.ResultsEtoposide solutions diluted at 0.38, 0.74 and 1.26 mg/mL in G5% and stored at 25°C were stable for 61 days and at 1.75 mg/mL for 28 days. In 0.9% NaCl, etoposide was less stable, with more precipitations observed. The action of an infusion pump has not caused any physical modifications.ConclusionStorage at 25°C and G5% as diluent are recommended for etoposide high concentration with 61-day stability up to a concentration of 1.26 mg/mL and 28-day stability up to a concentration of 1.75 mg/mL. As a precaution, the use of an administration set with an in-line micro-filter is nevertheless recommended. Storage at 2°C to 8°C and the use of 0.9% NaCl increase the risk of precipitation.

show abstract

Stability and compatibility of etoposide in 0.9% sodium chloride injection in three containers

Cited by 7 publications

References 0 publications

Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices

Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices

Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous etoposide solution

Physicochemical stability of etoposide diluted at range concentrations between 0.38 and 1.75 mg/mL in polyolefin bags

Contact Info

Product

Resources

About