Stability and CMC determinations of amphiphilic (DSPEPEG(3400)-CTT2) peptide constructs by microtensiometry

Tools to enable the study and translation of supramolecular amphiphiles

“…139 Stability strategies have been discussed by Lu and co-workers, 140 and stability assessments in biological media have been discussed by Feiner-Gracia and co-workers, 4 with other key introductory texts referenced here. 133,134,141…”

“…139 Stability strategies have been discussed by Lu and co-workers, 140 and stability assessments in biological media have been discussed by Feiner-Gracia and co-workers, 4 with other key introductory texts referenced here. 133,134,141 2.8.1 Physiological considerations for design of amphiphiles as drugs. Using biological factors as cues for rationally designed characteristics of a supramolecular amphiphile can facilitate a targeted ''smart'' drug design.…”

Reorganization energy and Stokes shift calculations from spectral data as new efficient approaches in distinguishing the end point of micellization/aggregation

“…6,7 Among the various probes, pyrene has been the most used one because the intensity and shape of the uorescence spectrum and lifetime are sensitive to the variation of the local environment. [8][9][10] Various other methods like electrochemical measurements using electrophoresis or capillary electrophoresis, 11,12 conductometric 13,14 and surface tension measurements, 15,16 optical measurements using light scattering 17 and optical bers, 18 and ITC, 19 chromatography, 20 and ultrasonic velocity 21 measurements were also used for the determination of the CMC. 22,23 The Stokes shi is an important property of a uorophore which is expressed as the difference of its emission and excitation maxima.…”