Background: A sense of place (SOP) is defined as the emotional bonds, values, meaning, and symbols attached to a place. Aim: To assess SOP of patients with cancer during end-of-life care at home (homehospice service) versus at a hospital in relation to place of care, social support, and emotional distress. Methods: Participants were 150, stage IV, cancer patients with a life expectancy of less than 6 months, as defined by oncological staff, who were not receiving any lifeprolonging care. Seventy-five patients received care at home (home-hospice), and the other 75 received care at the oncology department at the hospital, by palliative unit staff. Participants completed the Brief Symptom Inventory anxiety and depression subscales, questionnaires on perceived support and both questionnaires on home SOP and hospital SOP. Results: Mean scores of emotional distress were similar for patients in homehospice and at the hospital. Home SOP among individuals receiving care at home was high, and hospital SOP was high among hospitalized individuals. The structural equation model had good fit indexes, showing that each of the SOP variables mediated the association between place of care and emotional distress. Perceived support was associated with lower distress only in the hospital setting. Conclusions: The SOP concept is relevant to understanding emotional distress in relation to place of care at end of life. Strengthening SOP in relation to place of care should be considered. As newly introduced concept regarding place of care at the EoL, SOP warrants further research. K E Y W O R D S cancer, emotional distress, end-of-life care, home-hospice, hospital, perceived support, psycho-oncology, sense of place 1 | INTRODUCTION More than 6.5 million people in the world need palliative care services annually due to cancer. 1 The need for palliative care is increasing at a rapid pace due rising life expectancy and increases in cancer cases. 1 The place of care, either home or institutions such as hospitals, hospices, or nursing homes, has a substantial effect on the nature of care and subsequently, on patients' quality of life. 2 Although patients often prefer home as the place for care and death at end of life (EoL), some patients prefer to be treated at the hospital. 2,3 Preferring to receive care at hospitals was explained by fear of being a burden to family, whereas preferring to receive care at