Stability and bioactivity of peptides in food matrices based on processing conditions

Ashaolu, Tolulope Joshua; Le, Thanh-Do; Suttikhana, Itthanan

doi:10.1016/j.foodres.2023.112786

Cited by 9 publications

(3 citation statements)

References 125 publications

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“…Cleaving proteins to release peptides, aided by food-grade proteases (i.e., enzymatic hydrolysis) or by the action of microorganisms (i.e., fermentation), has been proved to enhance the techno-functional and biological properties of these components [ 3 , 4 , 5 ]. The properties of peptides are determined by the length, amino acid composition, position of each amino acid in the chain, charge, hydrophobicity, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Regarding other sources, a critical review on immunomodulatory peptides from plant sources; and action mechanisms and recent advances have been recently published [ 9 ]. Among the bioactivities more widely studied and described in literature, the antioxidant and antihypertensive properties of peptides can be highlighted [ 5 , 10 , 11 ], as well as anti-inflammatory or antidiabetic [ 12 , 13 ], though most of the reports published until now are in vitro assays and consequently, the scope and relevance of these studies are limited. This in vitro demonstration of bioactivity is not enough to determine the health-promoting activities of peptides but might serve as a screening of a huge number of candidates.…”

Section: Introductionmentioning

confidence: 99%

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Evidence of Immunomodulatory Food-Protein Derived Peptides in Human Nutritional Interventions: Review on the Outcomes and Potential Limitations

et al. 2023

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The immune system is somehow related to all the metabolic pathways, in a bidirectional way, and the nutritional interventions affecting these pathways might have a relevant impact on the inflammatory status of the individuals. Food-derived peptides have been demonstrated to exert several bioactivities by in vitro or animal studies. Their potential to be used as functional food is promising, considering the simplicity of their production and the high value of the products obtained. However, the number of human studies performed until now to demonstrate effects in vivo is still scarce. Several factors must be taken into consideration to carry out a high-quality human study to demonstrate immunomodulatory-promoting properties of a test item. This review aims to summarize the recent human studies published in which the purpose was to demonstrate bioactivity of protein hydrolysates, highlighting the main results and the limitations that can restrict the relevance of the studies. Results collected are promising, although in some studies, physiological changes could not be observed. When responses were observed, they sometimes did not refer to relevant parameters and the immunomodulatory properties could not be clearly established with the current evidence. Well-designed clinical trials are needed in order to evaluate the role of protein hydrolysates in immunonutrition.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evidence of Immunomodulatory Food-Protein Derived Peptides in Human Nutritional Interventions: Review on the Outcomes and Potential Limitations

et al. 2023

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“…Focusing on the use of these antioxidant compounds in the food industry, it is necessary to know their behavior when they are added to a food that can undergo further processing or conservation treatments, since these treatments can alter their composition and quantity [ 6 , 7 ]. It is also important to analyze their stability under different conditions and to identify and study the biological action of the end products [ 8 , 9 ]. On the other hand, since the ultimate goal of using these plant by-products is to obtain bioactive compounds, it is very important to demonstrate their bioaccesibility during the digestion process.…”

mentioning

confidence: 99%