Landslides are among the most severe natural hazards with significant impacts in human life and infrastructure. The Three Gorges Reservoir Area (TGRA) is vulnerable to landslides because of the geological environment and human activities. A centrifuge model test of a landslide with a planar sliding surface in the TGRA was conducted. Based on the multiple monitoring systems composed of a 3D laser scanner, pore water pressure transducers, particle image velocimetry and earth pressure sensors, multiphysical data were obtained. The work described here had the objective of researching the long-term deformation pattern of this kind of landslide that was subjected to periodic fluctuations in the reservoir water level. The results indicated that the failure processes were characterized by progressive retrogression and cracks caused by the reservoir drawdown. Transverse tensile cracks first appeared in the submerged zone of the slope. The front part of the slope was dominated by horizontal displacement, while the consolidation and compaction deformation in the vertical direction dominated at the mid-rear part of the slope. When the water level dropped again, the front part slid down and fell into the river, but the mid-rear part had no obvious deformation and exhibited a phenomenon of self-stabilization. Moreover, the phreatic line is a concave shape directed into the slope during reservoir filling and converts to a convex shape pointing out of the slope during reservoir drawdown. The earth pressures in the slope vary with the failure process of the landslide. Good agreement is obtained for the deformation characteristics between the experimental results and those of prototype landslides.