Stabilité galénique de mélanges commercialisés de nutrition parentérale en présence de médicaments : médicaments dans le mélange

Husson, Estelle; Crauste–Manciet, Sylvie; Hadj-Salah, Ève; Seguier, J.-C.; Brossard, Denis

doi:10.1016/s0985-0562(03)00006-2

Cited by 10 publications

(3 citation statements)

References 10 publications

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“…In addition, the results indicate that the composition of the concrete does not influence the evolution of the zeta potential of interstitial mediums. Similar results were obtained by Husson et al (2003) on the formation of emulsions. After the contact release agent/pore solution, the interstitial mediums form an emulsion in the vicinity of the formwork.…”

Section: Zeta Potential Of Interstitial Mediumssupporting

confidence: 89%

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Characterization of the Interface Between Fresh Concrete and Formwork

Bouharoun¹

2015

Journal of Civil Engineering and Management

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Abstract. Concrete surface quality is generally linked to the development conditions of concrete close to the formwork. This work aims to study the influence of the nature of release agent and the quantity of fine elements on the chemical interactions at the concrete/oil/formwork interface. Five concretes were prepared at 28, 30, 32, 34, and 36% of paste to study the influence of paste volume on the friction between formwork and fresh concrete. The friction tests were performed using an apparatus which can reproduce the same conditions of construction sites. In addition, a physicochemical investigation was achieved to identify the effect of fine elements on the ability to form the interstitial mediums at the interface. The formation of soap in the vicinity of the formwork surfaces was also studied as a function of the content and the nature of oils. The results showed that the friction between fresh concrete and formwork depends on the pore solution content present at the interface.

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Section: Zeta Potential Of Interstitial Mediumssupporting

confidence: 89%

“…In commercial emulsions, it is the additives associated with the surfactant used that create a negative PZ, in the range of -40 to -50 mV (Husson et al 2003). According to Washington (1992) and Washington et al (1989), the zone of instability of an emulsion is between -25 mV and +25 mV.…”

Section: Zeta Potential Of Interstitial Mediumsmentioning

confidence: 99%

Characterization of the Interface Between Fresh Concrete and Formwork

Bouharoun¹

2015

Journal of Civil Engineering and Management

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“…Nevertheless, considering our strong knowledge of parenteral emulsion design and stability [ 6 , 7 , 8 ], we decided to work on the feasibility of the process for hospital emergency preparation.…”

Section: Introductionmentioning

confidence: 99%

Hospital Production of Sterile 2% Propofol Nanoemulsion: Proof of Concept

et al. 2023

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In the context of essential drug shortages, this article reports a proof of concept for the hospital preparation of a 2% propofol injectable nanoemulsion. Two processes for propofol were assessed: mixing propofol with the commercial Intralipid® 20% emulsion and a “de novo” process performed using separate raw materials (i.e., oil, water, and surfactant) and optimized for droplet size reduction with a high-pressure homogenizer. A propofol HPLC-UV stability-indicating method was developed for process validation and short-term stability. In addition, free propofol in the aqueous phase was quantified by dialysis. To envision routine production, sterility and endotoxin tests were validated. Only the “de novo” process using high-pressure homogenization gave satisfactory physical results similar to commercialized Diprivan® 2%. Both terminal heat sterilization processes (121 °C, 15 min and 0.22 µm filtration) were validated, but an additional pH adjustment was required prior to heat sterilization. The propofol nanoemulsion was monodisperse with a 160 nm mean droplet size, and no droplets were larger than 5µm. We confirmed that free propofol in the aqueous phase of the emulsion was similar to Diprivan 2%, and the chemical stability of propofol was validated. In conclusion, the proof of concept for the in-house 2% propofol nanoemulsion preparation was successfully demonstrated, opening the field for the possible production of the nanoemulsion in hospital pharmacies.

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Nutrition parentérale: indications, apports, technique, produits, surveillance et complications

Bornet¹

2007

Acta Endosc

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Stabilité galénique de mélanges commercialisés de nutrition parentérale en présence de médicaments : médicaments dans le mélange

Cited by 10 publications

References 10 publications

Characterization of the Interface Between Fresh Concrete and Formwork

Characterization of the Interface Between Fresh Concrete and Formwork

Hospital Production of Sterile 2% Propofol Nanoemulsion: Proof of Concept

Nutrition parentérale: indications, apports, technique, produits, surveillance et complications

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