Abstract:Cell surface hypersialylation is used by malignant cells as a survival mechanism, leveraging interactions with inhibitory Siglec receptors to dampen immune rejection. In this study, we harnessed this mechanism to prevent autoimmune rejection of beta cells in the context of Type 1 Diabetes. Mice were engineered to express the sialyltransferase ST8Sia6 in a beta cell specific manner (βST mice) and crossed to the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. Both female and male litterm… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.