ST8Sia2 polysialyltransferase protects against infection byTrypanosoma cruzi
Bruno Rafael Barboza,
Janaina Macedo-da-Silva,
Lays Adrianne Mendonça Trajano Silva
et al.
Abstract:Glycosylation is one of the most structurally and functionally diverse co- and post-translational modifications in a cell. Addition and removal of glycans, especially to proteins and lipids, characterize this process which have important implications in several biological processes. In mammals, the repeated enzymatic addition of a sialic acid unit to underlying sialic acids (Sia) by polysialyltransferases, including ST8Sia2, leads to the formation of a sugar polymer called polysialic acid (polySia). The functi… Show more
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