ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 (ST3GAL4)

Schnaar, Ronald L.

doi:10.1007/978-4-431-54240-7_75

Handbook of Glycosyltransferases and Related Genes 2014

DOI: 10.1007/978-4-431-54240-7_75

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ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 (ST3GAL4)

Ronald L. Schnaar

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2023

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Glycosyltransferases as versatile tools to study the biology of glycans

Kofsky,

Babulic,

Boddington

et al. 2023

Glycobiology

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All cells are decorated with complex carbohydrate structures called glycans that serve as ligands for glycan-binding proteins (GBPs) to mediate a wide range of biological processes. Understanding the specific functions of glycans is key to advancing an understanding of human health and disease. However, the lack of convenient and accessible tools to study glycan-based interactions has been a defining challenge in glycobiology. Thus, the development of chemical and biochemical strategies to address these limitations has been a rapidly growing area of research. In this review, we describe the use of glycosyltransferases (GTs) as versatile tools to facilitate a greater understanding of the biological roles of glycans. We highlight key examples of how GTs have streamlined the preparation of well-defined complex glycan structures through chemo-enzymatic synthesis, with an emphasis on synthetic strategies allowing for site- and branch-specific display of glyco-epitopes. We also describe how GTs have facilitated expansion of glyco-engineering strategies, on both glycoproteins and cell surfaces. Coupled with advancements in bioorthogonal chemistry, GTs have enabled selective glyco-epitope editing of glycoproteins and cells, selective glycan subclass labeling, and the introduction of novel biomolecule functionalities onto cells, including defined oligosaccharides, antibodies, and other proteins. Collectively, these approaches have contributed great insight into the fundamental biological roles of glycans and are enabling their application in drug development and cellular therapies, leaving the field poised for rapid expansion.

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Glycosyltransferases as versatile tools to study the biology of glycans

Kofsky,

Babulic,

Boddington

et al. 2023

Glycobiology

View full text Add to dashboard Cite

show abstract

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ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 (ST3GAL4)

Cited by 1 publication

References 21 publications

Glycosyltransferases as versatile tools to study the biology of glycans

Glycosyltransferases as versatile tools to study the biology of glycans

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