ST2 silencing aggravates ventricular remodeling and chronic heart failure in rats by mediating the IL‐33/ST2 axis

Hai, Li; Zhao, Chen; Liu, Guo‐Hui

doi:10.1002/term.3091

Cited by 5 publications

(4 citation statements)

References 31 publications

(30 reference statements)

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“…Soluble suppression of tumorigenesis-2 (sST2), a member of the interleukin-1 receptor family, is a marker of ventricular mechanical stress. The secretion of sST2 in serum is markedly increased when cardiomyocytes are injured, myocardial fibrosis, or ventricular remodeling [ 59 , 60 ]. The prognostic value of sST2 in both acute and chronic HF has been proven.…”

Section: Resultsmentioning

confidence: 99%

Risk Prediction Models and Novel Prognostic Factors for Heart Failure with Preserved Ejection Fraction: A Systematic and Comprehensive Review

Lin,

Yang,

Liu

et al. 2023

CPD

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Background: Patients with heart failure with preserved ejection fraction (HFpEF) have large individual differences, unclear risk stratification, and imperfect treatment plans. Risk prediction models are helpful for the dynamic assessment of patients' prognostic risk and early intensive therapy of high-risk patients. The purpose of this study is to systematically summarize the existing risk prediction models and novel prognostic factors for HFpEF, to provide a reference for the construction of convenient and efficient HFpEF risk prediction models. Methods: Studies on risk prediction models and prognostic factors for HFpEF were systematically searched in relevant databases including PubMed and Embase. The retrieval time was from inception to February 1, 2023. The Quality in Prognosis Studies (QUIPS) tool was used to assess the risk of bias in included studies. The predictive value of risk prediction models for end outcomes was evaluated by sensitivity, specificity, the area under the curve, C-statistic, C-index, etc. In the literature screening process, potential novel prognostic factors with high value were explored. Results: A total of 21 eligible HFpEF risk prediction models and 22 relevant studies were included. Except for 2 studies with a high risk of bias and 2 studies with a moderate risk of bias, other studies that proposed risk prediction models had a low risk of bias overall. Potential novel prognostic factors for HFpEF were classified and described in terms of demographic characteristics (age, sex, and race), lifestyle (physical activity, body mass index, weight change, and smoking history), laboratory tests (biomarkers), physical inspection (blood pressure, electrocardiogram, imaging examination), and comorbidities. Conclusion: It is of great significance to explore the potential novel prognostic factors of HFpEF and build a more convenient and efficient risk prediction model for improving the overall prognosis of patients. This review can provide a substantial reference for further research.

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Section: Resultsmentioning

confidence: 99%

Risk Prediction Models and Novel Prognostic Factors for Heart Failure with Preserved Ejection Fraction: A Systematic and Comprehensive Review

Lin,

Yang,

Liu

et al. 2023

CPD

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“…The beneficial and harmful effects of the IL-33/ST2 axis in patients with CAD are debatable ( 34 , 42 – 44 ). Although several studies have reported the role of the IL-33/ST2 axis in CAD from a genetic perspective, the results remain controversial.…”

Section: Discussionmentioning

confidence: 99%

IL-33/ST2 immunobiology in coronary artery disease: A systematic review and meta-analysis

Liu

Liu²,

Wei³

et al. 2022

Front. Cardiovasc. Med.

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The IL-33/ST2 axis is reported to be controversially associated with coronary artery disease (CAD). A systematic review of the association between the IL-33/ST2 axis and CAD revealed that IL-33/ST2 plays a protective role in CAD and serum sST2 and IL-33 levels are increased in patients with cardiovascular disease. Therefore, the association of IL-33/ST2 single nucleotide polymorphisms (SNPs) with CAD prevalence, prognosis, and risk factors was assessed by performing a meta-analysis. Through a literature search of relevant articles in various databases using the relevant keywords, seven studies were included in the analysis. The meta-analysis showed that the IL-33/ST2 axis was associated with increased CAD risk [pooled odds ratio (OR) = 1.17, 95% confidence interval (CI): 1.13–1.20]. Gene subgroup analysis showed a close association of IL1RL1 (OR = 1.25, 95% CI: 1.20–1.30; I2 = 85.9%; p = 0.000) and IL1RAcP (OR = 1.42, 95% CI: 1.26–1.60; I2 = 27.1%; p = 0.203) with increased CAD risk. However, the association for the IL-33 gene was not statistically significant. SNPs rs7044343 (T), rs10435816 (G), rs11792633 (C) in IL-33 gene were associated with a protective effect in CAD. However, rs7025417 (T) in IL-33, rs11685424 (G) in IL1RL1, rs950880 (A) in sST2, and rs4624606 (A) in IL1RAcP were related to increased CAD risk. Overall, polymorphisms in IL-33/ST2 axis components were associated with increased CAD risk. These results may help identify key features of IL-33/ST2 immunobiology in CAD along with potential treatment strategies to lower disease burden.

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“…A clinical trial showed that the 5‐year mortality rate of hospitalized patients with CHF is as high as 50%, which seriously affects the physical and mental health of patients (Ma et al, 2020). Ventricular remodeling (VR) after acute myocardial infarction (AMI) is the main pathogenesis of CHF, which regulates the prognosis of AMI patients (Zhao et al, 2020). Actively exploring how to prevent VR after AMI, and delay the pathophysiological process of CHF is an inevitable choice to effectively improve the prognosis of patients with AMI and prevent and cure CHF.…”

Section: Introductionmentioning

confidence: 99%

Kaempferol‐3‐ O ‐rutinoside exerts cardioprotective effects through NF‐ κ B/NLRP3/Caspase‐1 pathway in ventricular remodeling after acute myocardial infarction

Fang

Zhang

et al. 2022

Journal of Food Biochemistry

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Ventricular remodeling (VR) after acute myocardial infarction (AMI) is the main pathogenesis of chronic heart failure (CHF). Kaempferol-3-O-rutinoside (KR) is the flavonoid glycoside with the highest content in Lu'an GuaPian tea, which has good pharmacological activities. However, the mechanism of KR against VR after AMI remains unclear. Molecular docking was used to predict the targets of KR on the NLRP3/Caspase-1 signaling pathway. Histological changes in the myocardium were visualized using HE staining, Masson staining. Cardiomyocyte apoptosis was detected using TUNEL. Immunohistochemistry was used to examine NLRP3, Caspase-1 p20, and GSDMD. IL-1β level in serum was detected using ELISA. Finally, the expressions of NF-κB p65, NLRP3, ASC, Caspase-1 p20, GSDMD, and IL-1β were measured using RT-PCR and Western blotting. Our results showed that KR had a good binding activity with NLRP3, Caspase-1, and GSDMD, significantly improved cardiac function, alleviated cardiac pathological changes, reduced the excessive deposition of myocardial interstitial collagen, and inhibited cardiomyocyte apoptosis in AMI rats. Furthermore, KR could decrease the IL-1β level and inhibit the expressions of NF-κB p65, NLRP3, ASC, Caspase-1 p20, GSDMD, and IL-1β. Our study suggests that KR can prevent and treat VR after AMI, and the protective effect is related to its regulatory NF-κB/ NLRP3/Caspase-1 signaling pathway. Practical applicationsKaempferol-3-O-rutinoside is present in Carthamus tinctorius L., Nymphaea candida, Afgekia mahidoliae and green tea, which has good pharmacological activities against liver injury, cerebral ischemia/reperfusion injury, dementia, hyperglycemia, and myocardial infarction. Our previous study found that kaempferol-3-O-rutinoside had an obvious anti-inflammatory effect, and could significantly improve the cell survival rate of H9c2 myocardium inflammatory injury induced by LPS. In this study, kaempferol-3-O-rutinoside significantly improved cardiac function, alleviated cardiac pathological changes, reduced the excessive deposition of myocardial interstitial collagen, and inhibited cardiomyocyte apoptosis in AMI rats. Furthermore, kaempferol-3-O-rutinoside

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ST2 silencing aggravates ventricular remodeling and chronic heart failure in rats by mediating the IL‐33/ST2 axis

Cited by 5 publications

References 31 publications

Risk Prediction Models and Novel Prognostic Factors for Heart Failure with Preserved Ejection Fraction: A Systematic and Comprehensive Review

Risk Prediction Models and Novel Prognostic Factors for Heart Failure with Preserved Ejection Fraction: A Systematic and Comprehensive Review

IL-33/ST2 immunobiology in coronary artery disease: A systematic review and meta-analysis

Kaempferol‐3‐ O ‐rutinoside exerts cardioprotective effects through NF‐ κ B/NLRP3/Caspase‐1 pathway in ventricular remodeling after acute myocardial infarction

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