ST2 and IL‐33 polymorphisms and the development of childhood asthma: a prospective birth cohort study in Finnish children
Johanna T. Teräsjärvi,
Laura Toivonen,
Jussi Mertsola
et al.
Abstract:The ST2/IL‐33 signaling pathway has an important role in the host inflammatory response. Here we aimed to study the association of ST2 and IL‐33 polymorphisms with serum soluble (s) ST2 and IL‐33 concentrations in healthy Finnish children and, in addition, their association with childhood asthma. In total, 146 children were followed from birth to the age 7 years for the development of asthma. Single‐nucleotide polymorphisms (SNPs) in ST2 and IL‐33 were determined, and associations of the SNP variants with seru… Show more
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