ST-Segment Elevation in Patients with Covid-19 — A Case Series

Bangalore, Sripal; Sharma, Atul; Slotwiner, Alexander J.; Yatskar, Leonid; Harari, Rafael; Shah, Binita; Ibrahim, Homam; Friedman, Gary H.; Thompson, Craig A.; Alviar, Carlos L.; Chadow, Hal; Fishman, Glenn I.; Reynolds, Harmony R.; Keller, Norma; Hochman, Judith S.

doi:10.1056/nejmc2009020

Cited by 728 publications

(744 citation statements)

References 3 publications

Supporting

Mentioning

664

Contrasting

Unclassified

Order By: Relevance

“…In data from 6 New York hospitals, only 8 out of 18 patients presenting with ST-elevation on the initial ECG had evidence of obstructive coronary disease on angiography or regional wall motion abnormalities on echocardiography. 7 MINOCA could be due to microvascular dysfunction, coronary thrombosis or embolism, plaque disruption of coronary dissection or vasospasm. In this regard, a higher incidence of coronary embolism has been reported, which probably relates to the prothrombotic state of COVID-19 patients, in whom a rise in D-dimers is commonly seen.…”

Section: Understanding the Cardiac Manifestations Of Covid-19mentioning

confidence: 99%

“…All rights reserved with higher median troponin and D-dimer levels than patients with non-coronary myocardial injury. 7 To further complicate the clinical picture, also other forms of stress-induced cardiomyopathy, such as takotsubo, hypoxia-induced cardiac injury, MOF or pulmonary embolism can result in a rise of cardiac troponin. These conditions can mimic, whether by symptoms or by changes in the baseline ECG, a true myocardial infarction.…”

Section: Accepted Articlementioning

confidence: 99%

See 1 more Smart Citation

Emerging cardiological issues during the COVID‐19 pandemic

Everaert¹,

Muylle²,

Twickler

2020

Eur J Clin Investigation

View full text Add to dashboard Cite

Today the modern world is facing an unprecedented health crisis. The COVID-19 pandemic is putting extensive strain on health care systems, hospitals and medical workers worldwide.Epidemiological data are emerging that COVID-19 patients with cardiac risk factors or preexisting cardiac conditions are at increased risk for complications and mortality from COVID-19.As we just begin to understand the pathophysiology underlying the disease, the involvement of the heart, whether through direct myocardial infection and damage or due to cardiac complications, is already evident. Also, the current therapy for COVID-19 using anti-viral agents, (hydroxy)chloroquine and other off-label used medications is not without risk for cardiac side effects. Furthermore, the pandemic puts stress on the organization of cardiac health care, both for COVID-19 patients as well as for the acute and chronic care of cardiac patients in which patient as well as physician-related delays in treatment could potentially lead to harm. Epidemiological data, are cardiac patients at higher risk?Is there a relation between cardiac risk factors or cardiac injury and the mortality risk in COVID-19? Early reports from China 1 indeed show markedly elevated mortality rates in patients with hypertension, diabetes and pre-existing coronary artery disease (up to 10-fold in the latter) compared to patients without underlying health conditions. In a recent report of Shi et al. 2 hospitalized COVID-19 patients in Wuhan, China, presenting with elevated high-sensitive cardiac troponin I levels had a higher frequency of complications such as ARDS (58.5% vs. 14.7%) and acute kidney injury (8.5 vs. 0.3%), required more invasive mechanical ventilation (22% vs. 4.2%) and had a significant increase in in-hospital mortality than patients without cardiac injury (51.2% vs. 4.5%). The percentage of hospitalized COVID-19 patients with elevated troponins is in the range of 20-28% 2,3 and in patients with pre-existing cardiovascular disease with elevated troponins the mortality can be as high as 69.4%. 3 These data indicate that patients with cardiac Accepted ArticleThis article is protected by copyright. All rights reserved risk factors or pre-existing coronary artery disease are at high risk during this COVID-19 pandemic and that cardiac injury is an important predictor of adverse outcomes.

show abstract

Section: Understanding the Cardiac Manifestations Of Covid-19mentioning

confidence: 99%

Section: Accepted Articlementioning

confidence: 99%

Emerging cardiological issues during the COVID‐19 pandemic

Everaert¹,

Muylle²,

Twickler

2020

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…2 For patients with refractory or recurrent chest pain, moderate elevation of troponin level or focal electrocardiogram changes, consider performing cardiac point-ofcare ultrasonography to assess for left ventricular dysfunction and coronary computed tomography (CT) angiography to rule out CAD. 2,4…”

Section: Myocardial Infarction (Mi) May Occur Without Obstructive Cormentioning

confidence: 99%

Cardiac considerations in patients with COVID-19

Calvillo‐Argüelles

Ross

2020

CMAJ

View full text Add to dashboard Cite

“…The most common radiographic findings are ground-glass opacity (56%) and bilateral patch shadowing (52%) on computed tomography (CT) [27]. Electrocardiogram may show nonspecific ST-T abnormalities in some cases [30,31], but the prevalence remains unknown. In laboratory tests, lymphocytopenia is commonly observed (83%) and most patients have elevated serum levels of C-reactive protein and proinflammatory cytokines [7,10].…”

Section: Introductionmentioning

confidence: 99%

Impact of COVID-19 on the Cardiovascular System: A Review

Matsushita

Marchandot

Jesel

et al. 2020

JCM

View full text Add to dashboard Cite

The recent outbreak of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 has been declared a public health emergency of international concern. COVID-19 may present as acute respiratory distress syndrome in severe cases, and patients with pre-existing cardiovascular comorbidities are reported to be the most vulnerable. Notably, acute myocardial injury, determined by elevated high-sensitivity troponin levels, is commonly observed in severe cases, and is strongly associated with mortality. Therefore, understanding the effects of COVID-19 on the cardiovascular system is essential for providing comprehensive medical care for critically ill patients. In this review, we summarize the rapidly evolving data and highlight the cardiovascular considerations related to COVID-19.

show abstract

ST-Segment Elevation in Patients with Covid-19 — A Case Series

Cited by 728 publications

References 3 publications

Emerging cardiological issues during the COVID‐19 pandemic

Emerging cardiological issues during the COVID‐19 pandemic

Cardiac considerations in patients with COVID-19

Impact of COVID-19 on the Cardiovascular System: A Review

Contact Info

Product

Resources

About