ST-segment dynamics during reperfusion period and the size of myocardial injury in experimental myocardial infarction

Demidova, Marina M.; Pals, Jesper van der; Ubachs, Joey F.A.; Kanski, Mikael; Engblom, Henrik; Erlinge, David; Tichonenko, V.M.; Platonov, Pyotr G.

doi:10.1016/j.jelectrocard.2010.10.035

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…Negative, non-significant correlation coefficients were obtained when ST 40 changes were correlated with MaR, in agreement with the results reported by Demidova et al (2011) when investigating ST level changes in a subset of the present population. Many other studies, however, have shown opposite results when correlating ST level and MaR, both in humans and in animal experiments (Kjekshus et al 1972, Lowe et al 1978, Christian et al 1995.…”

Section: Correlation Between Ecg Changes and The Amount Of Ischemiasupporting

confidence: 92%

“…A low resolution Butterworth filter with a cutoff frequency of 0.6 of Nyquist rate (half sampling rate) and order 5 was applied for iterative reconstruction using maximum likelihood-expectation maximization. Short-and long-axis images were reconstructed (Demidova et al 2011). To analyze the MPS images and assess the MaR the freely available software Segment v1.700 (Medviso, Lund, Sweden; http://segment.heiberg.se) was used (Heiberg et al 2010).…”

Section: Image Acquisition and Processing For Assessment Of Marmentioning

confidence: 99%

“…MPS was used to evaluate the amount of MaR (Heiberg et al 2010). A detailed description of experimental setup is given elsewhere (Demidova et al 2011).…”

Section: Study Populationmentioning

confidence: 99%

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Characterization of ventricular depolarization and repolarization changes in a porcine model of myocardial infarction

Romero¹,

Ringborn²,

Demidova³

et al. 2012

Physiol. Meas.

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In this study, several electrocardiogram (ECG)-derived indices corresponding to both ventricular depolarization and repolarization were evaluated during acute myocardial ischemia in an experimental model of myocardial infarction produced by 40 min coronary balloon inflation in 13 pigs. Significant changes were rapidly observed from minute 4 after the start of coronary occlusion, achieving their maximum values between 11 and 22 min for depolarization and between 9 and 12 min for repolarization indices, respectively. Subsequently, these maximum changes started to decrease during the latter part of the occlusion. Depolarization changes associated with the second half of the QRS complex showed a significant but inverse correlation with the myocardium at risk (MaR) estimated by scintigraphic images. The correlation between MaR and changes of the downward slope of the QRS complex, [Formula: see text], evaluated at the two more relevant peaks observed during the occlusion, was r = -0.75, p < 0.01 and r = -0.79, p < 0.01 for the positive and negative deflections observed in [Formula: see text], temporal evolution, respectively. Repolarization changes, analyzed by evaluation of ST segment elevation at the main observed positive peak, also showed negative, however non-significant correlation with MaR: r = -0.34, p = 0.28. Our results suggest that changes evaluated in the latter part of the depolarization, such as those described by [Formula: see text], which are influenced by R-wave amplitude, QRS width and ST level variations simultaneously, correlate better with the amount of ischemia than other indices evaluated in the earlier part of depolarization or during the ST segment.

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Section: Correlation Between Ecg Changes and The Amount Of Ischemiasupporting

confidence: 92%

Section: Image Acquisition and Processing For Assessment Of Marmentioning

confidence: 99%

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Characterization of ventricular depolarization and repolarization changes in a porcine model of myocardial infarction

Romero¹,

Ringborn²,

Demidova³

et al. 2012

Physiol. Meas.

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“…Experimental protocol A porcine model of myocardial infarction was used in this work. The experimental preparation and study protocol have been previously described in detail (18)…”

Section: Methodsmentioning

confidence: 99%

Transient and rapid QRS-widening associated with a J-wave pattern predicts impending ventricular fibrillation in experimental myocardial infarction

et al. 2014

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“…Se analizaron los registros de ECG de 26 cerdos sometidos a un modelo de infarto del miocardio a tórax cerrado mediante intervención coronaria percutánea (PCI) durante 40 minutos 3 , junto con sus registros basales. Se obtuvo la serie comparando la morfología de los intervalos Mean Warped T wave peak-to-end (MWTPE) a lo largo de los registros con un MWTPE de referencia.…”

Section: Introducción Métodosunclassified

Neurys Gómez - Los cambios en la morfología del intervalo Tpico-Tfin medidos mediante "time-warping" se asocian con la fibrilación ventricular inducida por la isquemia en un modelo porcino

Gómez

2023

Jorn. jovenes investig. I3A

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ST-segment dynamics during reperfusion period and the size of myocardial injury in experimental myocardial infarction

Cited by 12 publications

References 31 publications

Characterization of ventricular depolarization and repolarization changes in a porcine model of myocardial infarction

Characterization of ventricular depolarization and repolarization changes in a porcine model of myocardial infarction

Transient and rapid QRS-widening associated with a J-wave pattern predicts impending ventricular fibrillation in experimental myocardial infarction

Neurys Gómez - Los cambios en la morfología del intervalo Tpico-Tfin medidos mediante "time-warping" se asocian con la fibrilación ventricular inducida por la isquemia en un modelo porcino

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