St. John’s Wort Herbal Teas – Biological Potential and
            Chemometric Approach to Quality Control

Kladar, Nebojša; Anačkov, Goran; Srđenović, Branislava; Gavarić, Neda; Hitl, Maja; Salaj, Nebojša; Jeremić, K.; Babovic, Sinisa; Božin, Biljana

doi:10.1007/s11130-020-00823-1

Cited by 8 publications

(8 citation statements)

References 21 publications

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“…and 24.76-58.15 mg QE/g d.e., respectively. The recorded values correspond to previous analyses of these species [9,10], as well as to analyses of H. perforatum extracts [11,12]. The highest amount of phenolics was recorded in H. maculatum subsp.…”

Section: Chemical Characterization Of Hypericum Extractssupporting

confidence: 87%

“…Basically, preparations based on St. John's wort are being used in two forms, water-ethanolic extracts and oil macerates made of upper areal parts of H. perforatum. The first one has been shown to be clinically effective in the treatment of mild to moderate forms of depression, while oil macerate is being used traditionally externally for the treatment of wounds, bruises and eczema, as well as internally for the treatment of gastric ulcers [2,3]. Several classes of compounds with promising biological potential are present in H. perforatum.…”

Section: Introductionmentioning

confidence: 99%

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Biological Activity of Genus Hypericum Sect. Hypericum Species—H. tetrapterum, H. maculatum subsp. immaculatum, H. triquetrifolium

Kladar,

Božin,

Bijelić

et al. 2023

Molecules

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St. John’s wort (Hypericum perforatum, Hypericaceae) has long been used in traditional medicine as a potent remedy, while many other species of this genus have not been thoroughly investigated. The study aimed to detect the biological activity, including antioxidant, antihyperglycemic, anticholinergic, antimicrobial and monoaminoxidase inhibitory potential, of water-alcoholic extracts of three species autochthonous for Serbia and Greece from plant genus Hypericum (section Hypericum—H. tetrapterum, H. maculatum ssp. immaculatum and H. triquetrifolium), followed by phytochemical profiling. The highest amount of phenolics was recorded in H. maculatum subsp. immaculatum extract, while the highest abundance of flavonoids was characteristic of H. tetrapterum extract. Hypericin and hyperforin, quercetin, and its flavonoid, rutin, were present in all of the evaluated species. The evaluated species were good scavengers of DPPH, OH and NO radicals, as well as potent reducers of ferric ions in FRAP assay. Furthermore, the evaluated species were shown as potent inhibitors of monoaminoxidase A and α-glucosidase and modest inhibitors of acetylcholinesterase, monoaminoxidase B and α-amylase. No anti-Candida activity was recorded, but the extracts were effective against MRSA Staphylococcus aureus and Enterococcus sp., as well as against Proteus mirabilis. The obtained results strongly highlight the need for further in vivo studies in order to better define the potential of the medicinal application of the studied species.

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Section: Chemical Characterization Of Hypericum Extractssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Biological Activity of Genus Hypericum Sect. Hypericum Species—H. tetrapterum, H. maculatum subsp. immaculatum, H. triquetrifolium

Kladar,

Božin,

Bijelić

et al. 2023

Molecules

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“…Generally, the ability of plant extracts to reduce metal ions into NPs is attributed to their antioxidant activities. − H. perforatum extract exhibits several pharmacological properties due to its antioxidant activities, which have been demonstrated in several studies. − Although various classes of compounds are present in the H. perforatum extract, its antioxidant capacities are generally attributed to the presence of xanthones, flavonoids, and phenolic acids. ,− In the LPF used in the present study, xanthones and phloroglucinols are the major compounds, and its low antioxidant potential suggests that these classes of compounds might have not participated in the Ag + ion reduction.…”

Section: Resultsmentioning

confidence: 64%

Uncovering the Phytochemical Basis and the Mechanism of Plant Extract-Mediated Eco-Friendly Synthesis of Silver Nanoparticles Using Ultra-Performance Liquid Chromatography Coupled with a Photodiode Array and High-Resolution Mass Spectrometry

Pradeep

Kruszka

Kachlicki

et al. 2021

ACS Sustainable Chem. Eng.

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Plant extract is a complex concoction of several phytochemicals, for instance, phenolics, sugars, flavonoids, xanthones, and several others. In general, it is said that hydroxyl-rich phenolics act as reducing agents for metal ions, but little is discussed about the stabilizing ligands of metal nanoparticles (NPs). Thus, despite the popularity of plant extract-mediated synthesis of NPs, the phytochemical basis of the process and the exact mechanism are still unclear. Herein, a systematic study was carried out to unveil the mechanism of St. John's wort (Hypericum perforatum (H. perforatum) L.) extract-mediated synthesis of silver (Ag) NPs. Among the phytochemicals present in the extract, phenolic acids and flavonoids are shown to be involved in the reduction of Ag + ions, while xanthones and phloroglucinols act as capping agents, and naphthodianthrones were involved in both steps. Analysis of the postreaction residues by ultra-performance liquid chromatography coupled with a photodiode array and high-resolution mass spectrometry showed a sharp decrease in the concentration of various secondary metabolites present in the extract, of which large amounts of xanthones and phloroglucinols were recovered from the NPs. Consequently, the low polar fraction of H. perforatum extract, rich in xanthones and phloroglucinols, and the pure compounds of these classes (mangiferin and hyperforin) did not reduce Ag + ions. In contrast, the polar fraction of the extract, rich in flavonoids and naphthodianthrones, and the pure compounds of these classes (kaempferol-3-glucoside, quercetin, quercetin-3-glucoside, hypericin, pseudohypericin, and protohypericin) were able to reduce Ag + ions. Overall, the present study contributes significantly to the understanding of green synthesis of NPs by plant extracts.

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“…Currently, its main use is as an antidepressant [26][27][28]. These medicinal properties have also been described for several species of St. John's wort [29].…”

Section: Introductionmentioning

confidence: 99%

Human Health Risk Assessment of Arsenic and Other Metals in Herbal Products Containing St. John’s Wort in the Metropolitan Area of Mexico City

Rojas,

Ruiz-Sánchez,

Rojas

et al. 2023

Toxics

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Consumption of St. John’s wort plant is high worldwide due to its various medicinal properties. However, herbal products containing St. John’s wort may be contaminated with toxic metals. This is often related to contamination of both water and the atmosphere, lack of proper cultivation methods, and inadequate plant storage conditions, as well as a lack of stricter sanitary supervision. A safety assessment of copper (Cu), lead (Pb), cadmium (Cd) and arsenic (As) content in 23 products containing St. John’s wort (pharmaceutical herbal products, food supplements and traditional herbal remedies) sold in the metropolitan area of Mexico City was conducted. The analysis of metals was determined using a graphite-furnace atomic absorption spectrometer. All herbal products were contaminated with Cu, Pb, Cd and As. The pharmaceutical herbal items showed less contamination by metals. The daily human intake (DHI) values for Pb exceeded the permissible limits in the group of traditional herbal remedies. The DHI calculation for As exceeded the permitted intake values for all items in the group of traditional herbal remedies, five food supplements and one pharmaceutical herbal product. The hazard indicator calculation of the non-carcinogenic cumulative risk values for traditional herbal remedies was greater than 1, suggesting a risk to human health.

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St. John’s Wort Herbal Teas – Biological Potential and Chemometric Approach to Quality Control

Cited by 8 publications

References 21 publications

Biological Activity of Genus Hypericum Sect. Hypericum Species—H. tetrapterum, H. maculatum subsp. immaculatum, H. triquetrifolium

Biological Activity of Genus Hypericum Sect. Hypericum Species—H. tetrapterum, H. maculatum subsp. immaculatum, H. triquetrifolium

Uncovering the Phytochemical Basis and the Mechanism of Plant Extract-Mediated Eco-Friendly Synthesis of Silver Nanoparticles Using Ultra-Performance Liquid Chromatography Coupled with a Photodiode Array and High-Resolution Mass Spectrometry

Human Health Risk Assessment of Arsenic and Other Metals in Herbal Products Containing St. John’s Wort in the Metropolitan Area of Mexico City

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