St. John's Wort

Field, Howard L.; Monti, Daniel; Greeson, Jeffrey M.; Kunkel, E

doi:10.2190/pbfd-lwb4-u8cg-53c9

Cited by 11 publications

(7 citation statements)

References 66 publications

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“…Hypericum perforatum L. is a flowering herb native to Europe, North Africa, and Asia and commonly known as St. John's wort. It flowers in June around St. John the Baptist's day (24 June), which may have given the plant its common name [109] . The European herb has been used traditionally to treat several diseases since the ancient Greeks’ time.…”

Section: Resultsmentioning

confidence: 99%

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Natural Products for the Treatment of Drug Addiction: Narrative Review

Raslan

2022

Chemistry & Biodiversity

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Drug addiction is considered a chronic disorder affecting the individual's life, his/her family and society. Up till now the treatment of drug addiction is considered a problematic issue. Synthetic drugs available for the treatment of drug addiction are few, of limited efficacy and associated with serious side effects. Therefore, there is a continuous search for better therapeutic agents for drug addiction. Natural products represent a promising source for drug addiction treatment. This review summaries drug addiction definition, its mechanism of action, its types, its diagnosis, factors affecting its development and different available approaches for its treatment especially the use of natural products. Six plants were discussed thoroughly in this review, including, Tabernanthe

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Section: Resultsmentioning

confidence: 99%

“…It flowers in June around St. John the Baptist's day (24 June), which may have given the plant its common name. [109] The European herb has been used traditionally to treat several diseases since the ancient Greeks' time. It has been used to treat anxiety, depression, cuts, and burns.…”

Section: Tabernanthe Iboga Baill Iboga (Family: Apocynaceae)mentioning

confidence: 99%

Natural Products for the Treatment of Drug Addiction: Narrative Review

Raslan

2022

Chemistry & Biodiversity

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“…The flowers are believed to be the most abundant and brightest around the 24th of June, the day that is traditionally believed to be the birthday of St. John the Baptist (hence the name St. John's wort). 19 St. John's wort is a popular herbal remedy recommended by traditional herbal practitioners primarily for the treatment of depression. Furthermore, St. John's wort is licensed and widely prescribed for the treatment of depression in some European countries.…”

Section: St John's Wort: Clinical Efficacy Active Ingredients and Tox...mentioning

confidence: 99%

Utility of Therapeutic Drug Monitoring in Identifying Clinically Significant Interactions Between St. John's Wort and Prescription Drugs

Steenkamp

Parkar

Dasgupta

2023

Therapeutic Drug Monitoring

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Background:The general population widely uses herbal medicines, as they are regarded as effective and safe. St. John's wort, which is an effective herbal antidepressant, exhibits both pharmacokinetic and pharmacodynamic interactions with several drugs. The aim of this review was to highlight the clinically significant interactions of St. John's wort with drugs that require to be monitored to assess their therapeutic effect.Methods: Published literature was searched using electronic databases, such as MEDLINE, PubMed, and Elsevier ScienceDirect using terms such as "herbal medicine," "herbal toxicity," "legislation herbal medicine," "drug-herb interactions," "St. John's wort," and "St. John's wort-drug interactions." Searches were limited to the English language, and there was no restriction on the date of publication.Results: St. John's wort exhibits a number of pharmacokinetic and pharmacodynamic interactions with drugs. The most dangerous interactions occurred when used concurrently with the immunosuppressants, cyclosporine, and tacrolimus (treatment failure or organ rejection) or warfarin (treatment failure resulting in thromboembolic events) or antiretroviral agents (treatment failure and the emergence of new viral variants that are resistant to conventional drugs).Conclusions: Patients should consult their health care providers before consuming herbal supplements, especially St. John's wort, to avoid potentially dangerous drug-herb interactions.

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“…Johnʼs wort (H. perforatum) is a flowering plant of the Hypericaceae family native to Europe, North Africa, and Asia (Maron, Vilà, Bommarco, Elmendorf, & Beardsley, 2004). The bright, yellow flowers bloom in midsummer around St. John the Baptistʼs day in June, which may have given the plant its common name (Field, Monti, Greeson, & Kunkel, 2000). Chemically, Hypericum extracts contain a number of biologically active and complex compounds including naphthodianthrones (hypericin and pseudohypericin); phloroglucinol derivatives (hyperforin and adhyperforin); flavonoids (rutin, hyperoside, isoquercitrin, quercitrin, and quercetin); biflavonoids (I3, II8biapigenin, I3′, II8-biapigenin); proanthocyanidins; and chlorogenic acid (Li & Fitzloff, 2001).…”

Section: Hypericum Perforatummentioning

confidence: 99%

Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action

Zirak

Shafiee

Soltani

et al. 2018

Journal Cellular Physiology

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Background Psychiatric disorders are substantially associated with reduced quality of life and increased mortality. Depression and anxiety are two of the most common psychiatric disorders that often co‐occur with each other as well as with other mental health conditions. Because of the limitations of currently available antidepressant therapies, there is a need for agents with improved efficacy and less adverse effects. Hypericum perforatum, widely known as St. John's wort, is a perennial herbaceous plant most well known for its antidepressant properties. Methods We reviewed the available in vitro, in vivo, and clinical evidence on the efficacy, safety, and mechanisms of action of St. John's wort and its active constituents in the treatment of psychiatric and neurodegenerative disorders. Results Several interesting data have been reported about the antidepressant properties of H. perforatum in clinical trials with different designs. In particular, a number of antidepressant‐controlled trials demonstrated that H. perforatum and its active ingredients, hypericin and hyperforin, possess antidepressant properties similar to those of tricyclic antidepressants and selective serotonin reuptake inhibitors but with fewer and milder side effects. Conclusion St. John's wort may exert potent antidepressant effects and represents an efficacious and safe treatment. However, the current clinical evidence regarding the efficacy of H. perforatum in other psychiatric and neurodegenerative disorders is not sufficient to draw a robust conclusion.

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St. John's Wort

Cited by 11 publications

References 66 publications

Natural Products for the Treatment of Drug Addiction: Narrative Review

Natural Products for the Treatment of Drug Addiction: Narrative Review

Utility of Therapeutic Drug Monitoring in Identifying Clinically Significant Interactions Between St. John's Wort and Prescription Drugs

Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action

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