“…Johnʼs wort (H. perforatum) is a flowering plant of the Hypericaceae family native to Europe, North Africa, and Asia (Maron, Vilà, Bommarco, Elmendorf, & Beardsley, 2004). The bright, yellow flowers bloom in midsummer around St. John the Baptistʼs day in June, which may have given the plant its common name (Field, Monti, Greeson, & Kunkel, 2000). Chemically, Hypericum extracts contain a number of biologically active and complex compounds including naphthodianthrones (hypericin and pseudohypericin); phloroglucinol derivatives (hyperforin and adhyperforin); flavonoids (rutin, hyperoside, isoquercitrin, quercitrin, and quercetin); biflavonoids (I3, II8biapigenin, I3′, II8-biapigenin); proanthocyanidins; and chlorogenic acid (Li & Fitzloff, 2001).…”