SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target

Emanuel, Oscar; Liu, Jacklyn; Schartinger, Volker Hans; Nei, Wen Long; Chan, Yuk Yu; Tsang, Chi Man; Riechelmann, Herbert; Masterson, Liam; Haybaeck, Johannes; Oppermann, Udo; Willems, Stefan M.; Ooft, Marc Lucas; Wollmann, Guido; Howard, David; Vanhaesebroeck, Bart; Lund, Valerie J.; Royle, G.; Chua, Melvin L.K.; Lo, Kwok Wai; Busson, P.; Lechner, Matt

doi:10.3390/cancers13194944

Cited by 10 publications

(7 citation statements)

References 87 publications

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“…In addition, NF-κB signalling may also be affected by the activation of EBV-miR-BART13, which is a type of EBV miRNA. In vivo and in vitro studies have shown that these miRNAs can promote the growth and metastasis of NPC cells [41,42]. MAPK plays a vital role in the process of cell proliferation, differentiation, transformation, and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Potential Biomarkers in Early-Stage Nasopharyngeal Carcinoma Based on Platelet RNA Sequencing

Chen

et al. 2022

Mol Biotechnol

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Early diagnosis is essential for the treatment and prevention of nasopharyngeal cancer. However, there is a lack of effective biological indicators for nasopharyngeal carcinoma (NPC). Therefore, we explored the potential biomarkers in tumour-educated blood platelet (TEP) RNA in early NPC. Platelets were isolated from blood plasma and their RNA was extracted. High-throughput sequenced data from a total of 33 plasma samples were analysed using DESeq2 to identify the differentially expressed genes (DEGs). Subsequently, the DEGs were subjected to principal component analysis (PCA), gene ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis; and Cytoscape, TargetScan, and miRanda software were used for inferring the competing endogenous RNA network. We identified 19 long non-coding (lnc) RNAs (DElncRNAs) and 248 mRNAs (DEmRNAs) that were differentially expressed in the TEP RNA. In addition, SELP gene mRNA and lncRNAs AC092135.3, AC012358.2, AL021807.1, AP001972.5, and GPX1 were found to be down-regulated DEmRNA and DElncRNAs in the early stage of NPC. Bioinformatic analysis showed that these DEmRNAs and DElncRNAs may be involved in regulating the pathogenesis of NPC. Our research may provide new insights for exploring the biological mechanisms of NPC and early diagnosis using potential biomarkers.

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Section: Discussionmentioning

confidence: 99%

Prediction of Potential Biomarkers in Early-Stage Nasopharyngeal Carcinoma Based on Platelet RNA Sequencing

Chen

et al. 2022

Mol Biotechnol

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“…Emanuel, O. et al [ 19 ] offered a comprehensive and up-to-date summary of NPC, focusing on the role of somatostatin receptor 2 (SSTR2), a key tumour biomarker and promising target for imaging and therapy.…”

Section: Ebv-associated Malignancies and Ebv-targeted Therapiesmentioning

confidence: 99%

Epstein–Barr Virus Infection in Cancer

Mundo,

Leoncini,

Accardi-Gheit

2023

Cancers

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“…Persistently elevated EBV antibody levels are considered a major risk factor for NPC. [1][2][3] NPC is a regional cancer, with high incidence rates in southern China and Southeast Asia. 2 4 The disease is classified into two types based on histological analysis: nonkeratinising squamous cell carcinoma and keratinising squamous cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma

Xu,

Quan,

Zhan

et al. 2023

J Clin Pathol

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AimsEpidermal growth factor receptor (EGFR) belongs to the receptor tyrosine kinases family and overexpression of EGFR has been linked to poor prognosis and cancer progression. Somatostatin receptor 2 (SSTR2) is a G-protein-coupled receptor (GPCR) with diverse biological functions in humans, and it is upregulated through the NF-KB signalling pathway in nasopharyngeal carcinomas (NPC). However, no studies have examined the EGFR and SSTR2 in NPC. This study aimed to investigate whether SSTR2 is associated with EGFR and clinicopathological features in NPC.MethodsBioinformatics analysis was performed to assess the correlation between EGFR and SSTR2 based on the GEO database. The expression of SSTR2 and EGFR was evaluated by immunohistochemistry (IHC) in 491 cases of NPC and 50 cases of non-cancerous nasopharyngeal epithelium.ResultsThe bioinformatics analysis and IHC showed a positive correlation between SSTR2 and EGFR in NPC. High expression of SSTR2 and EGFR was significantly increased in NPC patients compared with non-cancerous nasopharyngeal epithelium. High expression of SSTR2 and/or EGFR was associated with a worse outcome and a higher risk of progression. The study found that patients receiving chemoradiotherapy (CR) with high expression of SSTR2, high expression of EGFR, and high coexpression of SSTR2 and EGFR had a poorer prognosis in both progression-free survival (PFS) and overall survival (OS). Interestingly, NPC patients with high expression of SSTR2, high expression of EGFR, high coexpression of EGFR and SSTR2, and EGFR/SSTR2 anyone high expression had a better prognosis with CR combined with targeted therapy. Cox multivariate analysis identified SSTR2 and EGFR as independent poor predictors of PFS.ConclusionOur study is the first to shed light on the intricate relationship between SSTR2 and EGFR in NPC and provides new insights into the potential benefits of EGFR targeted therapy for patients with high SSTR2 expression. Additionally, SSTR2 has potential as a new biomarker for poor prognosis in NPC patients.

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SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target

Cited by 10 publications

References 87 publications

Prediction of Potential Biomarkers in Early-Stage Nasopharyngeal Carcinoma Based on Platelet RNA Sequencing

Prediction of Potential Biomarkers in Early-Stage Nasopharyngeal Carcinoma Based on Platelet RNA Sequencing

Epstein–Barr Virus Infection in Cancer

SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma

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