SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the α4β2 nicotinic acetylcholine receptor [<sup>123</sup>I]5‐I‐A85380 ligand: In vivo and in vitro evidence

Cavanagh, Jonathan; Patterson, James C.; Pimlott, Sally L.; Wyper, David J.; Dewar, Deborah

doi:10.1002/syn.20705

Cited by 1 publication

(2 citation statements)

References 16 publications

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“…However, this finding is consistent with a previous study showing that treatment with selective serotonin reuptake inhibitors (SSRIs) did not have an effect on [ 123 I]5IA binding (40). Although SSRIs have been shown to block nAChRs, these effects appear to be non-competitive through actions on the channel pore (41).…”

Section: Discussionsupporting

confidence: 92%

“…For example, bupropion is a noncompetitive high-affinity nAChR antagonist (43) and may alter β 2 *-nAChR V T / f P . Some reports also suggest SSRIs may weakly bind to β 2 *-nAChR; however, a [ 123 I]5IA SPECT study showed that SSRI treatment did not affect radio-ligand binding (i.e., receptor availability) (40). Because we did not include a homogenous sample of medications, evaluations and conclusions of the effect of medications on β 2 *-nAChR are limited.…”

Section: Discussionmentioning

confidence: 99%

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Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography

Hannestad

Cosgrove

DellaGioia

et al. 2013

Biological Psychiatry

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Background The cholinergic system is substantially altered in individuals with major depression and is partially restored when depression remits. We quantified the availability of β2-subunit-containing nicotinic acetylcholine receptors (β2*-nAChR) in subjects with bipolar disorder. Methods Twenty-five subjects with bipolar disorder (15 depressed, 10 euthymic) and 25 sex- and age-matched control subjects had a [123I]5IA-85380 single photon emission computed tomography scan to quantify β2*-nAChR VT/fP (total volume of distribution, corrected for individual differences in metabolism and protein binding of the radiotracer). Average VT/fP was compared between groups and correlated with clinical characteristics. Postmortem analysis of β2*-nAChRs was conducted using equilibrium binding with [125I]5IA in subjects with bipolar disorder and matched control subjects. Results We showed significantly lower β2*-nAChR availability (20%–38%) in subjects with bipolar depression compared with euthymic and control subjects across all brain regions assessed (frontal, parietal, temporal, and anterior cingulate cortex, hippocampus, amygdala, thalamus, striatum). The postmortem binding study in which endogenous acetylcholine was washed out did not show a statistically significant difference in β2*-nAChR number in temporal cortex of the bipolar depressed and control groups (15% difference; p = .2). Conclusions We show that the alteration in the cholinergic system observed during a depressive episode appears to resolve during euthymia. We suggest that lower VT/fP observed in vivo may be due to a combination of higher endogenous acetylcholine levels during depression, which could compete with radiotracer binding to the receptor in vivo, and lower receptor number in bipolar depression. Identification of differences in cholinergic signaling in subjects with bipolar depression may improve our understanding of its etiology and reveal new treatment targets.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography

Hannestad

Cosgrove

DellaGioia

et al. 2013

Biological Psychiatry

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SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the α4β2 nicotinic acetylcholine receptor [¹²³I]5‐I‐A85380 ligand: In vivo and in vitro evidence

Abstract: SPECT imaging studies using [(123)I]5-I-A85380 to measure alpha4beta2 nAChR availability in depressed patients are unlikely to be confounded to a major degree by concurrent antidepressant medication.

Cited by 1 publication

References 16 publications

Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography

Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography

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SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the α4β2 nicotinic acetylcholine receptor [123I]5‐I‐A85380 ligand: In vivo and in vitro evidence

Abstract: SPECT imaging studies using [(123)I]5-I-A85380 to measure alpha4beta2 nAChR availability in depressed patients are unlikely to be confounded to a major degree by concurrent antidepressant medication.

Cited by 1 publication

References 16 publications

Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography

Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography

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SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the α4β2 nicotinic acetylcholine receptor [¹²³I]5‐I‐A85380 ligand: In vivo and in vitro evidence