ß-endorphin-immunoreactivity in the ventricular CSF and plasma of comatose patients

Hamel, E.; Allolio, Bruno

doi:10.1007/bf01790684

Cited by 1 publication

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“…Experimental studies concerning the intraventricular application of opioid peptides [12] have suggested an opioid influence on the state of consciousness. Furthermore, increased [3-endorphine levels in the CSF have been observed in relation to consciousness disturbances following cerebral infarction [2], or acute stroke [10].…”

Section: Introductionmentioning

confidence: 99%

CSF-endorphines in acute and chronic brain lesions

Hamel

1988

Neurosurg. Rev.

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In order to answer the question of an opioid influence on consciousness, a radio-immuno-assay (n = 852) of beta-endorphin and beta-LPH (beta-lipotropic hormone) in both ventricular CSF and blood plasma was carried out in 101 neurosurgical patients. The following results were obtained: I) beta-END and beta-LPH levels were found to be lower in the CSF than in blood plasma. II) beta-END and beta-LPH in the CSF was the same in both sexes. III) beta-END levels in the CSF decreased with age. IV) beta-END and beta-LPH levels showed a diurnal rhythm with a maximum in the late a. m. hours. V) beta-END levels in the ventricular CSF tend to decrease parallel to a drop in conciousness as well as with longlasting comatous states. VI) beta-END in ventricular CSF becomes higher with increasing systolic arterial blood pressure. VII) beta-END and beta-LPH levels in ventricular CSF are not correlated with the type of the disease, CSF pressure, body temperature or respiratory changes.

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Section: Introductionmentioning

confidence: 99%

CSF-endorphines in acute and chronic brain lesions

Hamel

1988

Neurosurg. Rev.

View full text Add to dashboard Cite

show abstract

ß-endorphin-immunoreactivity in the ventricular CSF and plasma of comatose patients

Cited by 1 publication

References 10 publications

CSF-endorphines in acute and chronic brain lesions

CSF-endorphines in acute and chronic brain lesions

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