SRPK1/AKT axis promotes oxaliplatin-induced anti-apoptosis via NF-κB activation in colon cancer

Huang, Jing-Qiang; Li, He-Feng; Zhu, Jing; Song, Junwei; Zhang, Xianbin; Gong, Peng; Liu, Qiu-Yu; Zhou, Chengyu; Wang, Liang; Gong, Li‐ping

doi:10.1186/s12967-021-02954-8

Cited by 23 publications

(18 citation statements)

References 34 publications

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“…The current author proposes that primary afferent peripheral terminal hyperexcitation with “leakiness” at Piezo2 is such a pathological condition in DOMS. Accordingly, it is not surprising that platinum-analogue drugs also elevate ROS production as the primary mechanism of platinum-induced peripheral neuropathy [ 110 ] with the activation of the NF-kappa B pathway [ 111 ].…”

Section: Oxidative Stress and Redox Imbalancementioning

confidence: 99%

Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation

Sonkodi

2022

Biomolecules

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Piezo2 transmembrane excitatory mechanosensitive ion channels were identified as the principal mechanotransduction channels for proprioception. Recently, it was postulated that Piezo2 channels could be acutely microdamaged on an autologous basis at proprioceptive Type Ia terminals in a cognitive demand-induced acute stress response time window when unaccustomed or strenuous eccentric contractions are executed. One consequence of this proposed transient Piezo2 microinjury could be a VGLUT1/Ia synaptic disconnection on motoneurons, as we can learn from platinum-analogue chemotherapy. A secondary, harsher injury phase with the involvement of polymodal Aδ and nociceptive C-fibers could follow the primary impairment of proprioception of delayed onset muscle soreness. Repetitive reinjury of these channels in the form of repeated bout effects is proposed to be the tertiary injury phase. Notably, the use of proprioception is associated with motor learning and memory. The impairment of the monosynaptic static phase firing sensory encoding of the affected stretch reflex could be the immediate consequence of the proposed Piezo2 microdamage leading to impaired proprioception, exaggerated contractions and reduced range of motion. These transient Piezo2 channelopathies in the primary afferent terminals could constitute the critical gateway to the pathophysiology of delayed onset muscle soreness. Correspondingly, fatiguing eccentric contraction-based pathological hyperexcitation of the Type Ia afferents induces reactive oxygen species production-associated neuroinflammation and neuronal activation in the spinal cord of delayed onset muscle soreness.

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Section: Oxidative Stress and Redox Imbalancementioning

confidence: 99%

Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation

Sonkodi

2022

Biomolecules

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“…SRPK1 silencing was found to promote cleaved poly (ADP-ribose) polymerase (PARP) and b-cell lymphoma extra S (BCL-xS) expression in cancer cells. NF-κB signalling was also found to be downregulated in response to SRPK1 silencing and this was associated with a significant reduction in oxaliplatin IC50 values on MTT assay [30]. Plascencia et al, also previously provided evidence linking SRPK1 expression to oxaliplatin resistance in colorectal cancer [59].…”

Section: Colorectal Cancermentioning

confidence: 84%

“…Thirteen studies explored the role of SRPK1 in colorectal cancer [3,25,[27][28][29][30][55][56][57][58][59][60][61]. SRPK1 expression was generally found to be elevated in colorectal cancer, with the exception of the mucinous subtype [3, 25, 27-30, 60, 61] (Table 1).…”

Section: Colorectal Cancermentioning

confidence: 99%

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Serine-Arginine Protein Kinase 1 (SRPK1): a systematic review of its multimodal role in oncogenesis

et al. 2022

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Alternative splicing is implicated in each of the hallmarks of cancer, and is mechanised by various splicing factors. Serine-Arginine Protein Kinase 1 (SRPK1) is an enzyme which moderates the activity of splicing factors rich in serine/arginine domains. Here we review SRPK1’s relationship with various cancers by performing a systematic review of all relevant published data. Elevated SRPK1 expression correlates with advanced disease stage and poor survival in many epithelial derived cancers. Numerous pre-clinical studies investigating a host of different tumour types; have found increased SRPK1 expression to be associated with proliferation, invasion, migration and apoptosis in vitro as well as tumour growth, tumourigenicity and metastasis in vivo. Aberrant SRPK1 expression is implicated in various signalling pathways associated with oncogenesis, a number of which, such as the PI3K/AKT, NF-КB and TGF-Beta pathway, are implicated in multiple different cancers. SRPK1-targeting micro RNAs have been identified in a number of studies and shown to have an important role in regulating SRPK1 activity. SRPK1 expression is also closely related to the response of various tumours to platinum-based chemotherapeutic agents. Future clinical applications will likely focus on the role of SRPK1 as a biomarker of treatment resistance and the potential role of its inhibition.

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“…The target genes of FOXP4-AS1 were further predicted and functionally annotated. SNORA56, SRPK1, and PRICKLE4 were significantly co-expressed with FOXP4-AS1 and played significant roles in breast cancer (34), NPC (35), HCC (36), lung adenocarcinoma (37), colon cancer (38) and ovarian cancer (39). Additionally, it has been shown that FOXP4-AS1 was interrelated with various functions, including double-strand AS1 may be associated with DNA replication, transcription, and cell cycle phase of tumor cells.…”

Section: Discussionmentioning

confidence: 99%

FOXP4-AS1 May be a Potential Prognostic Biomarker in Human Cancers: A Meta−Analysis and Bioinformatics Analysis

et al. 2022

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BackgroundCancer is one of the leading causes of death worldwide. Early diagnosis can significantly lower cancer-related mortality. Studies have shown that the lncRNA Forkhead box P4 antisense RNA 1 (FOXP4-AS1) is aberrantly expressed in various solid tumors. A meta-analysis was performed to evaluate the correlation of FOXP4-AS1 with the prognosis of cancer patients and determine the clinical value of FOXP4-AS1 as a potential diagnostic marker.MethodsCorrelational studies from the Web of Science, Embase, OVID, Cochrane and PubMed databases were screened (up to April 1, 2021). Meta-analysis was performed using Stata SE12.0 software.ResultsEleven original studies with 1,332 patients who were diagnosed with a solid cancer (nasopharyngeal carcinoma, hepatocellular carcinoma, colorectal cancer, gastric cancer, osteosarcoma, mantle cell lymphoma, prostate cancer, and pancreatic ductal adenocarcinoma) were included in the meta-analysis. High expression of FOXP4-AS1 was correlated with poor overall survival (OS) (HR = 1.77, 95% CI 1.29–2.44, P < 0.001) and shorter disease−free survival (DFS) (HR = 1.66, 95% CI 1.01–2.72, P = 0.044). Subgroup analysis based on sample size, follow-up time and Newcastle-Ottawa Scale (NOS) score revealed significant differences between FOXP4-AS1 levels and OS (P < 0.05). However, the expression level of FOXP4-AS1 was not significantly correlated with the OS of gastric cancer patients (P = 0.381). High expression of FOXP4-AS1 was predictive of a larger tumor size (OR = 3.82, 95% CI 2.3–6.3, P < 0.001).ConclusionsOverexpression of FOXP4-AS1 correlates with poor prognosis of cancer patients, and is a potential prognostic biomarker and therapeutic target.Systematic Review RegistrationPROSPERO, identifier CRD42021245267.

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SRPK1/AKT axis promotes oxaliplatin-induced anti-apoptosis via NF-κB activation in colon cancer

Cited by 23 publications

References 34 publications

Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation

Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation

Serine-Arginine Protein Kinase 1 (SRPK1): a systematic review of its multimodal role in oncogenesis

FOXP4-AS1 May be a Potential Prognostic Biomarker in Human Cancers: A Meta−Analysis and Bioinformatics Analysis

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