Srinivasan (1962–2021) in Bioinformatics and beyond

Gromiha, M. Michael; Orengo, Christine A.; Sowdhamini, Ramanathan; Thornton, Janet

doi:10.1093/bioinformatics/btac054

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The Alpha and The Omega Of The β1

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2022

2023

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Cited by 2 publications

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“…This article is dedicated to Prof. N. Srinivasan, a true master of protein structural bioinformatics, who passed away on 3 September 2021 [ 3 , 4 , 5 , 6 ].…”

Section: Forewordsmentioning

confidence: 99%

See 1 more Smart Citation

A Perspective on the (Rise and Fall of) Protein β-Turns

Brevern

2022

IJMS

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The β-turn is the third defined secondary structure after the α-helix and the β-sheet. The β-turns were described more than 50 years ago and account for more than 20% of protein residues. Nonetheless, they are often overlooked or even misunderstood. This poor knowledge of these local protein conformations is due to various factors, causes that I discuss here. For example, confusion still exists about the assignment of these local protein structures, their overlaps with other structures, the potential absence of a stabilizing hydrogen bond, the numerous types of β-turns and the software’s difficulty in assigning or visualizing them. I also propose some ideas to potentially/partially remedy this and present why β-turns can still be helpful, even in the AlphaFold 2 era.

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“…This article is dedicated to Prof. N. Srinivasan, a true master of protein structural bioinformatics, who passed away on 3 September 2021 [ 3 , 4 , 5 , 6 ].…”

Section: Forewordsmentioning

confidence: 99%

“…At the beginning of the 1990s, C.M. Wilmot and J. Thornton analyzed the β-turns in the light of Ramachandran plot regions (defined by six regions: αR, βE, βP, αL, γL and ε) for their two central residues [ 4 ]. They defined 16 types; half of them have an occurrence of less than 1% [ 69 ].…”

Section: The Alpha and The Omega Of The βmentioning

confidence: 99%