SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development

Han, Daehee; Jeon, Shin Teo; Lee, Changjin; Ahn, Soo Whan; Kim, Won Kyu; Chung, Hyun Kee; Seong, Rho Hyun

doi:10.1016/j.ydbio.2007.12.024

Cited by 40 publications

(30 citation statements)

References 49 publications

(56 reference statements)

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“…BRM has non-redundant roles with BRG1 during some, but not all, developmental processes in embryogenesis (Smith-Roe and Bultman, 2013). The associated subunits, BAF155, BAF47 and BAF250A are also required for peri-implantation development Guidi et al, 2001;Han et al, 2008;Kim et al, 2001;Klochendler-Yeivin et al, 2000;Roberts et al, 2000), further establishing the crucial role of BAF subunits during early embryonic development.…”

Section: From Implantation Through To Gastrulationmentioning

confidence: 95%

ATP-dependent chromatin remodeling during mammalian development

2016

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Precise gene expression ensures proper stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian development. ATP-dependent chromatin-remodeling complexes utilize the energy from ATP hydrolysis to reorganize chromatin and, hence, regulate gene expression. These complexes contain diverse subunits that together provide a multitude of functions, from early embryogenesis through cell differentiation and development into various adult tissues. Here, we review the functions of chromatin remodelers and their different subunits during mammalian development. We discuss the mechanisms by which chromatin remodelers function and highlight their specificities during mammalian cell differentiation and organogenesis.

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Section: From Implantation Through To Gastrulationmentioning

confidence: 95%

ATP-dependent chromatin remodeling during mammalian development

2016

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“…BAF155 knockout embryos die around the time of implantation, and ICMs from knockout blastocysts fails to form in vitro (37). We reasoned that BAF155 depletion also would impair ES cell maintenance.…”

Section: Unique Composition Of Baf Components In Es Cells: Esbafmentioning

confidence: 99%

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency

Ronan²,

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

514

658

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Mammalian SWI/SNF [also called BAF (Brg/Brahma-associated factors)] ATP-dependent chromatin remodeling complexes are essential for formation of the totipotent and pluripotent cells of the early embryo. In addition, subunits of this complex have been recovered in screens for genes required for nuclear reprogramming in Xenopus and mouse embryonic stem cell (ES) morphology. However, the mechanism underlying the roles of these complexes is unclear. Here, we show that BAF complexes are required for the self-renewal and pluripotency of mouse ES cells but not for the proliferation of fibroblasts or other cells. Proteomic studies reveal that ES cells express distinctive complexes (esBAF) defined by the presence of Brg (Brahma-related gene), BAF155, and BAF60A, and the absence of Brm (Brahma), BAF170, and BAF60C. We show that this specialized subunit composition is required for ES cell maintenance and pluripotency. Our proteomic analysis also reveals that esBAF complexes interact directly with key regulators of pluripotency, suggesting that esBAF complexes are specialized to interact with ES cell-specific regulators, providing a potential explanation for the requirement of BAF complexes in pluripotency.BAF complexes ͉ BAF155 ͉ Brg E S cells are pluripotent cells capable of both limitless selfrenewal and differentiation into all embryonic lineages. These abilities are conferred by various mechanisms, including transcription factors (1-3), possibly Polycomb complexes (4, 5), microRNAs (6), and histone modification enzymes (7) that work in coordination to maintain the expression of pluripotency genes while repressing lineage-determinant genes. The involvement of such mechanisms in pluripotency has been investigated extensively in recent years (reviewed in ref. 8), but the role of chromatin remodeling enzymes remains unclear.The mammalian genome encodes about 30 SWI2/SNF2-like ATPases, which are assembled into SWI/SNF-like complexes with ATP-dependent chromatin remodeling activity. Of these, Brg and Brm are alternative ATPases of a family of 2-MDa multisubunit SWI/SNF or BAF complexes and make up the prototypic mammalian SWI/SNF-like chromatin remodeling complexes (9, 10). BAF complexes have been shown to be essential for many aspects of mammalian development (11-13). A role of BAF complexes in pluripotency is suggested by observations that deletion of Brg, BAF155 (or Srg3), and BAF47 (or hSNF5) all lead to peri-implantation lethality and failure of the totipotent cells that give rise to both the inner cell mass and trophoblast to survive and grow (14-16). The catalytic ATPase subunit, Brg, also was recovered in screens for factors essential for nuclear reprogramming (17) and to ES cell morphology (18). In addition, ES cells lacking BAF250 have defects in ES cell maintenance and differentiation (19,20). However, the mechanism by which BAF complexes help to establish and maintain pluripotency is not understood.In vitro, BAF complexes use energy generated from ATP hydrolysis to alter DNA-nucleosome contacts (21) and can also e...

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“…Homozygous BAF155 knockout mice develop to early implantation stage but undergo rapid degeneration thereafter (Han et al, 2008). About 20% of BAF155 heterozygous mutant embryos display defects in brain development, angiogenesis and visceral endoderm development in the yolk sac (Han et al, 2008).…”

Section: Swi/snf Subunits and Their Role In Gene Regulation And Cancermentioning

confidence: 99%

“…About 20% of BAF155 heterozygous mutant embryos display defects in brain development, angiogenesis and visceral endoderm development in the yolk sac (Han et al, 2008). BAF155 has been shown to stabilize BAF47, BRG1 and BAF60A by attenuating their proteosomal degradation (Sohn et al, 2007).…”

Section: Swi/snf Subunits and Their Role In Gene Regulation And Cancermentioning

confidence: 99%

The SWI/SNF complex and cancer

2009

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The mammalian SWI/SNF complexes mediate ATPdependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).

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SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development

Cited by 40 publications

References 49 publications

ATP-dependent chromatin remodeling during mammalian development

ATP-dependent chromatin remodeling during mammalian development

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency

The SWI/SNF complex and cancer

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