Sr2+ vs. Ca2+ as post-processing ionic crosslinkers: implications for 3D bioprinting of polysaccharide hydrogels in tissue engineering

Vajda, Jernej; Vihar, Boštjan; Ćurić, Laura Činč; Maver, Uroš; Vesenjak, Matej; Dubrovski, Polona Dobnik; Milojević, Marko

doi:10.1016/j.jmrt.2023.01.149

Cited by 9 publications

(4 citation statements)

References 58 publications

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“…As the hydrogel swells, it can facilitate a controlled and sustained release of the nanoparticles, ensuring an optimal concentration at the application site over an extended period. As our research employs polysaccharide hydrogels, which have well-documented swelling characteristics, this property is inherent to our materials [ 2 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…SrCl 2 for 60 min. We utilized SrCl 2 as an ionic crosslinker owing to its specific properties, which were found to be superior for this application compared to the commonly used crosslinkers such as CaCl 2 [ 23 ]. Sr 2+ -crosslinked scaffolds demonstrate higher compressive strength, faster swelling, slower degradation, and a rougher surface [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…We utilized SrCl 2 as an ionic crosslinker owing to its specific properties, which were found to be superior for this application compared to the commonly used crosslinkers such as CaCl 2 [ 23 ]. Sr 2+ -crosslinked scaffolds demonstrate higher compressive strength, faster swelling, slower degradation, and a rougher surface [ 23 ]. These characteristics enhance the mechanical stability and the longevity of the dressing, potentially improving cell attachment and the interaction with melanoma cells.…”

Section: Methodsmentioning

confidence: 99%

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Development of a novel NiCu nanoparticle-loaded polysaccharide-based hydrogel for 3D printing of customizable dressings with promising cytotoxicity against melanoma cells

Ćurić,

Šuligoj,

Ibic

et al. 2023

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Development of a novel NiCu nanoparticle-loaded polysaccharide-based hydrogel for 3D printing of customizable dressings with promising cytotoxicity against melanoma cells

Ćurić,

Šuligoj,

Ibic

et al. 2023

Materials Today Bio

Self Cite

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“…While this idea does seem promising, there has been a lack of relevant research in the field. In our previous studies, we have shown that 3D printing can be used to optimise the mechanical properties, biocompatibility and other properties of various formulations [ 107 , 108 , 109 , 110 ], which can be transferred to the preparation of novel lenses. In this sense, there are also a lot of opportunities to transfer this knowledge to ophthalmology and prepare therapeutic lenses with desired transparency, mechanical properties, resisting tear and wear, and providing personalised drug delivery tailored to specific patient/disease needs.…”

Section: Future Prospectsmentioning

confidence: 99%

Review of Potential Drug-Eluting Contact Lens Technologies

Lovrec-Krstič,

Orthaber,

Maver

et al. 2023

Materials

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The field of ophthalmology is expanding exponentially, both in terms of diagnostic and therapeutic capabilities, as well as the worldwide increasing incidence of eye-related diseases. Due to an ageing population and climate change, the number of ophthalmic patients will continue to increase, overwhelming healthcare systems and likely leading to under-treatment of chronic eye diseases. Since drops are the mainstay of therapy, clinicians have long emphasised the unmet need for ocular drug delivery. Alternative methods, i.e., with better compliance, stability and longevity of drug delivery, would be preferred. Several approaches and materials are being studied and used to overcome these drawbacks. We believe that drug-loaded contact lenses are among the most promising and are a real step toward dropless ocular therapy, potentially leading to a transformation in clinical ophthalmic practice. In this review, we outline the current role of contact lenses in ocular drug delivery, focusing on materials, drug binding and preparation, concluding with a look at future developments.

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Advanced polymer composites and polymer hybrids for cartilage tissue engineering

Liu,

Hu,

et al. 2024

Polymer Composites

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The repair and regeneration of cartilage is a challenge for scientists and clinical surgery. Achieving cell adhesion and regeneration, anti‐inflammatory, lubrication, targeted drug delivery and controlled release simultaneously in cartilage treatment are the goals of researchers. Polymer composites and hybrids have the potential to realize above functions in cartilage tissue engineering. This review refers to cartilage injuries, current clinical techniques, and their benefits and limitations, focusing on the most relevant and state of art of advanced polymers for cartilage tissue engineering. The frontier applications of multifunctional polymer composites and hybrids in cartilage tissue engineering are discussed in depth, including polymer scaffold, polymer bio‐lubricant, and zwitterionic polymer for drug delivery and sustained drug release. A summary of comprehensive properties of polymers such as processability, mechanical properties, biocompatibility, biodegradability, hydrophilicity, cytotoxicity, etc., and their mechanisms are analyzed. Furthermore, some key challenges and outstanding concerns on polymer‐based materials for cartilage tissue engineering are presented followed by future perspectives.Highlights The state of art of advanced polymers for cartilage tissue engineering. The advanced bionic property and mechanism of polymer composites and hybrids. Polymers for scaffold, biolubricant, drug delivery, sustained drug release. Future perspectives on polymer composites, hybrids‐based cartilage materials.

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Sr2+ vs. Ca2+ as post-processing ionic crosslinkers: implications for 3D bioprinting of polysaccharide hydrogels in tissue engineering

Cited by 9 publications

References 58 publications

Development of a novel NiCu nanoparticle-loaded polysaccharide-based hydrogel for 3D printing of customizable dressings with promising cytotoxicity against melanoma cells

Development of a novel NiCu nanoparticle-loaded polysaccharide-based hydrogel for 3D printing of customizable dressings with promising cytotoxicity against melanoma cells

Review of Potential Drug-Eluting Contact Lens Technologies

Advanced polymer composites and polymer hybrids for cartilage tissue engineering

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