Sr2+ can Pass through Ca2+ Entry Pathway Activated by Ca2+ Depletion, but can be Hardly Taken up by the Ca2+ Stores in the Rat Salivary Acinar Cells.

Identification of Cyclic ADP-ribose-dependent Mechanisms in Pancreatic Muscarinic Ca2+ Signaling Using CD38 Knockout Mice

“…The cells, attached to a glass coverslip, were placed in a small chamber (400 l) mounted on the stage of an inverted microscope and perfused continuously (0.5 ml/min) with a stream of the experimental solution. This arrangement permitted a rapid exchange of the bathing solution (17). The fluorescence was measured by an epifluorescence inverted microscope system described previously (18,19).…”

Competitive metal‐binding stoichiometry between calcium and strontium by cell wall proteins of Neurospora crassa

“…For example, cell wall adsorption of Sr 2+ resulted in a stoichiometric release of Ca 2+ and Mg 2+ from the alga Vaucheria sp., indicating binding of these ions to equivalent functional groups at the cell surface [12]. Furthermore, a common system is known to mediate the active uptake of Sr 2+ , Ca 2+ , and Mg 2+ in microbes, plants, and animals, albeit with a lower affinity for Sr 2+ than for Ca 2+ or Mg 2+ [13,14]. The purpose of this investigation was to isolate and characterize the CWP of N. crassa and to demonstrate competitive stoichiometry between essential Ca 2+ , and nonessential Sr 2+ ions for the metal-binding sites on CWP and their role in metal-protein structure stabilizing property.…”