Squirrel Monkeys and Space Motion Sickness

Matsunami, Kazutoshi

doi:10.2170/jjphysiol.52.1

Cited by 4 publications

(4 citation statements)

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“…Both the Rhesus and squirrel monkeys have been used in blood pressure research [ 5 , 6 , 7 ], locomotion and postural behavior studies [ 8 ], stability during ambulation [ 9 ] and aerospace physiology [ 10 ]. Fluid redistribution between different body segments during postural changes may be an influencing factor in all of these cases.…”

Section: Introductionmentioning

confidence: 99%

Segmental volume changes that occur in nonhuman primates during short term head up (HUT) and head down (HDT) tilt

Montgomery¹,

Oloff²

2020

Journal of Electrical Bioimpedance

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Nonhuman primates are often used in biomedical research and to investigate physiologic processes that occur in man. Impedance plethysmography was used to measure calf, thigh, pelvic, abdominal, and thoracic volume changes in ten Rhesus and eight squirrel monkeys during five-minute exposures to HUT and HDT at angles of 5, 10, and 20 degrees. Calf, rump and tail measurements were made in three squirrel monkeys at 10 and 20 degrees of HUT and HDT. Fluid volume changes in all segments of the Rhesus monkeys were found to change during HUT an HDT in direct relation to the angle of tilt used. However, the volume changes that occurred in the squirrel monkeys were found to be quite different. Their calf, thigh, and pelvic segments lost volume during both HUT and HDT while their abdominal and thoracic segments responded similarly to those of the Rhesus monkeys. These results and those of the calf/tail measurements of the squirrel monkeys suggest that they may utilize their tails as a compensatory reservoir during postural changes and therefore, may not be an appropriate animal model for man under some orthostatic test conditions.

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Section: Introductionmentioning

confidence: 99%

Segmental volume changes that occur in nonhuman primates during short term head up (HUT) and head down (HDT) tilt

Montgomery¹,

Oloff²

2020

Journal of Electrical Bioimpedance

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“…Several previous studies also validated that a functional vestibular apparatus was necessary for provocative rotation-induced pica and conditioned taste aversions in rats [11,20] , and motion-induced emesis in dogs and squirrel monkeys [3,4] . Thereby, the vestibular apparatus is undoubtedly necessary for causing MS in animals with or without the emetic reflex.…”

Section: Discussionmentioning

confidence: 69%

“…In addition, bilateral chemical labyrinthectomy completely prevented emesis to the types of motion, such as body rotation in squirrel monkeys, which normally induce MS with vomiting or retching [3] . Patients with vestibular dysfunction did not experience MS either.…”

Section: Discussionmentioning

confidence: 97%

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Pica Behavior Induced by Body Rotation in Mice

Zhang²,

Zheng³

et al. 2008

ORL

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Objectives: To study whether rotational stimulus induced pica and whether the vestibular apparatus was necessary for obtaining rotation-induced pica in mice. Methods: Pica behavior in mice was investigated following 60 min of rotation once daily at 70 rpm (15 s on with 5 s off) for 3 consecutive days. After evaluating vestibular function and histology of vestibular epithelia, we examined rotation-induced kaolin intake, so-called pica, in sham-lesioned and chemically labyrinthectomized mice. Results: The labyrinthectomized mice exhibited loss of the contact righting and swimming capability while the destruction of hair cells of vestibular epithelia was observed. Moreover, mice subjected to rotation, but not labyrinthectomized mice, showed a significant increase in kaolin intake at the last 2 rotation sessions and the first postrotation session. Conclusions: The findings indicated that a functioning vestibular system is necessary for rotation-evocating pica in mice and thus pica can be a behavioral index of motion sickness in mice.

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