Squarroside a, a biologically active triterpene saponin from Acanthophyllum squarrosum

Saponins as immunoadjuvants and immunostimulants

“…A new acylated gypsogenin heptaglycoside (9) from Acanthophyllum squarrosum showed a concentration-dependent immunomodulatory effect in the in vitro lymphocyte transformation test [54]. At high concentrations (10 Ilg/ml), the saponin showed an immunosuppressive effect (60%) whereas the same compound displayed immunostimulating activity at very low concentrations (10 pg/ml).…”

Biologically and Pharmacologically Active Saponins from Plants: Recent Advances

“…Some compounds, such as squarroside A from Acanthophyllum squarrosum, showed at higher concentrations (100 or 200 IlglmL) inhibition of thymidine incorporation seen as an immunosupressive effect [26]. Only few examples of in vivo immunostimulating activities have been reported; for example curculigosaponin G [27] and formosanin C [28].…”

Isolation, Characterization and Study of Enhancing Effects on Nasal Absorption of Insulin in Rat of the Total Saponin from Acanthophyllum squarrosum

“…[14] Briefly, the roots were collected from around the city of Tabas, north of Yazd Province, Iran and identified by Fersdowsi University of Mashhad. Voucher samples were preserved for reference in the herbarium of the Department of Pharmacognosy, School of Pharmacy, Mashhad (Voucher no.…”