Squaraine dyes as fluorescent turn-on sensors for the detection of porcine gastric mucin: A spectroscopic and kinetic study

Butnarasu, Cosmin; Barbero, Nadia; Barolo, Claudia; Visentin, Sonja

doi:10.1016/j.jphotobiol.2020.111838

Cited by 13 publications

(16 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1, it is possible to verify that in aqueous media the four dyes tend to form aggregates, which is evidenced by the presence of two slightly overlapping bands, one of which is relative to the monomer and the other to the formed aggregates. This trend is already widely reported in the literature (42)(43)(44)(45) and is associated with the low solubility of squaraine dyes in aqueous media. The aggregates can be classified into J-aggregates and H-aggregates, which is related to the type of alignment of the transition dipole moments on adjacent molecules (46,47).…”

Section: Photophysical Studiessupporting

confidence: 67%

Squaraine Dyes Derived from Indolenine and Benzo[e]indole as Potential Fluorescent Probes for HSA Detection and Antifungal Agents

Gomes

Ferreira

Boto

et al. 2022

Photochem & Photobiology

View full text Add to dashboard Cite

Four squaraine dyes derived from 2,3,3-trimethylindolenine and 1,1,2-trimethyl-1H-benzo[e]indole with different combinations of barbituric groups attach to the central ring, having ester groups and alkyl chains in the nitrogen atoms of heterocyclic rings were synthesized. These dyes were fully characterized, and their photophysical behavior was studied in ethanol and phosphate-buffered solution. Absorption and emission bands between 631 and 712 nm were detected, with the formation of aggregates in aqueous media, which is typical of this class of dyes. Tests carried out with 1,3diphenylisobenzofuran allowed us to verify the ability of the dyes to produce singlet oxygen. The interaction of synthesized dyes with human serum albumin (HSA) was also evaluated, being demonstrated a linear correlation between fluorescence intensity and protein concentration. The antifungal potential of the dyes against the yeast Saccharomyces cerevisiae was evaluated using a broth microdilution assay. In order to test the photosensitizing capacity of the synthesized dyes, tests were carried out in the dark and with irradiation, using a custom-built light-emitting diode that emits close to the absorption wavelength of the studied dyes. The results showed that the interaction of dyes with HSA and the antifungal activity depends on the different structural modifications of the dyes.

show abstract

Section: Photophysical Studiessupporting

confidence: 67%

Squaraine Dyes Derived from Indolenine and Benzo[e]indole as Potential Fluorescent Probes for HSA Detection and Antifungal Agents

Gomes

Ferreira

Boto

et al. 2022

Photochem & Photobiology

View full text Add to dashboard Cite

show abstract

“…28,29 In addition, studies have shown that the binding of squaraine aggregates to mucin can effectively prevent self-aggregation and produce fluorescence enhancement. 30 This effectively solves the low fluorescence intensity and low quantum yield caused by the self-aggregation of general dyes in aqueous solutions.…”

Section: Squarainementioning

confidence: 99%

New insight into the application of fluorescence platforms in tumor diagnosis: From chemical basis to clinical application

Chen²,

Pan

et al. 2022

Medicinal Research Reviews

View full text Add to dashboard Cite

Early and rapid diagnosis of tumors is essential for clinical treatment or management. In contrast to conventional means, bioimaging has the potential to accurately locate and diagnose tumors at an early stage. Fluorescent probe has been developed as an ideal tool to visualize tumor sites and to detect biological molecules which provides a requirement for noninvasive, real-time, precise, and specific visualization of structures and complex biochemical processes in vivo. Rencently, the development of synthetic organic chemistry and new materials have facilitated the development of near-infrared small molecular sensing platforms and nanoimaging platforms. This provides a competitive tool for various fields of bioimaging such as biological structure and function imaging, disease diagnosis, in situ at the in vivo level, and real-time dynamic imaging. This review systematically focused on the recent progress of small molecular near-infrared fluorescent probes and nano-fluorescent probes as new biomedical imaging tools in the past 3-5 years, and it covers the application of tumor biomarker sensing, tumor microenvironment imaging, and tumor vascular imaging, intraoperative guidance and as an integrated platform for diagnosis, aiming to provide

show abstract

“…Benefiting from this versatility, squaraines have been extensively used in applications such as solar cells, [171][172][173][174] colorimetric sensing, [175][176] photothermal therapy [177][178] and imaging. [179][180][181] Squaraines whose synthesis has been first reported in 1965 [182] have seen their chemical structures to drastically evolve since these pioneering works and 1,2-and 1,3squaraines, symmetrical and asymmetrically substituted structures can be now selectively prepared. Notably, if the synthesis of 1,3-squaraines is known since decades, the regioselective synthesis of 1,2-squaraines has only been developed in 2011, explaining still the scarcity of the family of squaraines.…”

Section: Type I Photoinitiatorsmentioning

confidence: 99%

Recent advances on squaraine-based photoinitiators of polymerization

Giacoletto

Ibrahim‐Ouali

Dumur

2021

European Polymer Journal

View full text Add to dashboard Cite

The development of photoinitiating systems activable in the visible and the nearinfrared region is an active research field. Compared to the traditional UV photopolymerization for which the light penetration into the photocurable resin remains limited, a significant enhancement of this latter can be obtained in the visible and the near infrared range so that the scope of applications of photopolymerization can be revolutionized. Among dyes whose absorption can be facilely tuned, squaraines can be cited as relevant examples. Depending on the peripheral groups introduced on both sides of the central fourmembered squaric ring, absorptions ranging from 400 to 1000 nm can be obtained. In this review, an overview of the recent development concerning the squaraines-based photoinitiating systems is provided. To evidence the interest of these new photoinitiating systems, comparisons with reference systems will be established.

show abstract

Squaraine dyes as fluorescent turn-on sensors for the detection of porcine gastric mucin: A spectroscopic and kinetic study

Cited by 13 publications

References 45 publications

Squaraine Dyes Derived from Indolenine and Benzo[e]indole as Potential Fluorescent Probes for HSA Detection and Antifungal Agents

Squaraine Dyes Derived from Indolenine and Benzo[e]indole as Potential Fluorescent Probes for HSA Detection and Antifungal Agents

New insight into the application of fluorescence platforms in tumor diagnosis: From chemical basis to clinical application

Recent advances on squaraine-based photoinitiators of polymerization

Contact Info

Product

Resources

About