Squamous intraepithelial lesions of the cervix, invasive cervical carcinoma, and immunosuppression induced by human immunodeficiency virus in africa

Ruche, Guy La; Ramón, Rosa; Mensah-Ado, Isabelle; Bergeron, Christine; Diomandé, Mohamed; Sylla-Koko, F; Ehouman, A.; Toure-Coulibaly, K.; Welffens-Ekra, Christiane; Dabis, François

doi:10.1002/(sici)1097-0142(19980615)82:12<2401::aid-cncr14>3.0.co;2-t

Cited by 42 publications

(35 citation statements)

References 32 publications

(25 reference statements)

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“…However, given the high response rate [11,18], it was possible to identify the significant contribution of tobacco smoking and chewing on the risk of cervical HSIL. The presence of tobacco carcinogens in cervical mucus has been described as a possible biological explanation for the epidemiological association [40].…”

Section: Discussionmentioning

confidence: 99%

“…The subjects, the study design, and the methods of data collection have been described previously [11,18].…”

Section: Study Populationsmentioning

confidence: 99%

“…In Côte d'Ivoire, a cross-sectional study was conducted from April 1995 to February 1996 in three outpatient gynecology clinics of Abidjan [11]. A total of 2,198 women attending the clinics were eligible for the study as they fulfilled the following inclusion criteria: age between 20 and 50 years, absence of history of lower genital tract neoplasia, and absence of active pregnancy.…”

Section: Study Populationsmentioning

confidence: 99%

“…Data collection and definition of terms for tobacco smoking/chewing exposure In both studies, a questionnaire was administered to each participant to obtain information on smoking and chewing habits [11,18]. Tobacco smoking was defined in terms of use of cigarettes, pipe, and cigars.…”

Section: Study Populationsmentioning

confidence: 99%

“…A number of studies restricted to HPV DNA-positive women have shown an increased risk for CC in smokers compared to non-smokers [9,10]. In less industrialized countries, exposure to tobacco is more common through chewing than smoking among women [11][12][13]. However, less attention has been paid to the potential link between tobacco chewing and cervical neoplasia despite the fact that the developing countries bear the heaviest burden of CC.…”

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confidence: 99%

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Tobacco smoking and chewing as risk factors for multiple human papillomavirus infections and cervical squamous intraepithelial lesions in two countries (Côte d’Ivoire and Finland) with different tobacco exposure

Simen-Kapeu¹,

Ruche

Kataja

et al. 2008

Cancer Causes Control

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Our objective was to compare the association between tobacco smoking and chewing and the risk of multiple human papillomavirus (HPV) infections and cervical squamous intraepithelial lesions (SILs) in two populations with different tobacco exposure. We studied 2,162 women from Côte d'Ivoire, West Africa, and 419 women from Finland, Northern Europe, with baseline data on cervical screening, HPV DNA status and smoking and chewing habits. The proportion of women who smoked and/or chewed tobacco was higher in Finland (36.8%) than in Côte d'Ivoire (3.7%), where tobacco chewing (2.6%) was more common than tobacco smoking (1.4%). Having multiple HPV infections was common in HPV16 and/or 18-infected women (60.4% in Finland and 47.2% in Côte d'Ivoire). There was no increased risk of multiple HPV infections among tobacco consumers. We found that women >or=30 years of age exposed to tobacco through smoking in Finland (OR: 2.2, 95% CI: 0.5-8.7) and chewing in Côte d'Ivoire (OR: 5.5, 95% CI: 2.1-14) had a moderately or highly increased risk of high-grade SIL, respectively. In the latter, the risk was statistically significant. Our findings emphasize the need for health initiatives targeted to prevent tobacco smoking or chewing among women especially in less industrialized countries.

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Section: Discussionmentioning

confidence: 99%

“…The subjects, the study design, and the methods of data collection have been described previously [11,18].…”

Section: Study Populationsmentioning

confidence: 99%

Section: Study Populationsmentioning

confidence: 99%

Section: Study Populationsmentioning

confidence: 99%

mentioning

confidence: 99%

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Tobacco smoking and chewing as risk factors for multiple human papillomavirus infections and cervical squamous intraepithelial lesions in two countries (Côte d’Ivoire and Finland) with different tobacco exposure

Simen-Kapeu¹,

Ruche

Kataja

et al. 2008

Cancer Causes Control

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Cancer incidence in Abidjan, Ivory Coast

Echimane

Ahnoux

Adoubi

et al. 2000

Cancer

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Cervical cancer in patients infected with the human immunodeficiency virus

Leitao

White²,

Cracchiolo³

2008

Cancer

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BACKGROUND.The objective of this study was to compare the human immunodeficiency virus (HIV) viral load (VL) and CD4 counts in patients infected with HIV with and without cervical cancer. The authors hypothesized that HIV‐positive women with cervical cancer would have a greater risk of immune suppression.METHODS.A case–control study was conducted that included all HIV‐positive patients who were seen at the authors' institution from January 1, 1995 to April 20, 2006 with invasive cervical cancer (cases) and without invasive cervical cancer (controls). Patients were included only if they had a CD4 count recorded <6 months before or <3 months after their diagnosis of invasive cervical cancer (cases) or at their last gynecologic examination (controls). Controls were matched to cases on a 4:1 ratio according to current smoking history. Patients were considered immunocompetent if they had both a CD4 count >200 cells/μL and a VL <10,000 copies/mL.RESULTS.In total, 15 cases and 60 controls were identified. The median CD4 count for cases was 208 cells/μL (range, 18‐1102 cells/μL) compared with 445 cells/μL (range, 20‐1201 cells/μL) for controls (P = .03). The median VL was 16,918 copies/mL (range, 50‐214,915 copies/mL) for cases compared with 1430 copies/mL (range, 50‐571,000 copies/mL) for controls (P = .15). Only 1 of 14 cases (7%) was immunocompetent compared with 35 of 55 controls (64%; odds ratio, 0.04; 95% confidence interval, 0‐0.37; P < .001). This significance was maintained after adjusting for other factors (P = .002).CONCLUSIONS.Women with HIV who were diagnosed with invasive cervical cancer appeared to have a much greater degree of immunosuppression than women with HIV without invasive cervical cancer. Cancer 2008. © 2008 American Cancer Society.

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Squamous intraepithelial lesions of the cervix, invasive cervical carcinoma, and immunosuppression induced by human immunodeficiency virus in africa

Cited by 42 publications

References 32 publications

Tobacco smoking and chewing as risk factors for multiple human papillomavirus infections and cervical squamous intraepithelial lesions in two countries (Côte d’Ivoire and Finland) with different tobacco exposure

Tobacco smoking and chewing as risk factors for multiple human papillomavirus infections and cervical squamous intraepithelial lesions in two countries (Côte d’Ivoire and Finland) with different tobacco exposure

Cancer incidence in Abidjan, Ivory Coast

Cervical cancer in patients infected with the human immunodeficiency virus

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