Squamous cell carcinoma with rhabdoid phenotype and osteoclast-like giant cells in a renal–pancreas transplant recipient

Aljerian, Khaldoon; Alsaad, Khaled O.; Chetty, Runjan; Ghazarian, Danny

doi:10.1136/jcp.2005.034991

Cited by 14 publications

(12 citation statements)

References 18 publications

(15 reference statements)

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“…The observation to date has been made in the context of malignant melanoma, 5 squamous cell carcinoma, 6,7 and an adnexal carcinoma. 8 In each of the carcinomas, the giant cells were associated exclusively with sarcomatoid elements of the neoplasm.…”

Section: Introductionmentioning

confidence: 99%

Osteoclast-Like Giant Cell Reaction Associated With Cutaneous Squamous Cell Carcinoma: A Report of 2 Cases and Review of the Literature

Wooff

Werner²,

Murphy³

et al. 2009

The American Journal of Dermatopathology

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The observation of osteoclast-like giant cells (O-LGCs) in intimate association with visceral malignancies is an uncommon phenomenon that has been recognized for over 40 years. Recently, the same observation has been made in relation to cutaneous malignancies. In an article published in 2005, O-LGCs were documented in association with 3 melanomas, and since then, there have been 3 separate case reports recording the presence of these cells in cutaneous carcinomas. In the context of both visceral and cutaneous malignancies, the exact nature of the O-LGCs has been a source of controversy, with respect to whether they represent modified tumor cells or an unusual host response to the neoplasm. We report here 2 additional cases of cutaneous squamous cell carcinoma associated with O-LGCs. The morphological pattern of the giant cell proliferation differed between these cases, taking the form of (1) a giant cell tumor-like nodule apposed to the carcinoma in one and (2) scattered O-LGCs interspersed with tumor cells in the other. Based on scrutiny of routine sections and the contrasting immunohistochemical profiles of the O-LGCs versus the carcinomas, showing CD68 positivity on one hand and high-molecular weight keratin and p63 positivity on the other, we concluded that in both instances, the O-LGC proliferation was a reactive phenomenon. This theory is supported by most publications on the subject. Clinical and histopathological details of the new cases are outlined and integrated with those in the literature.

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Section: Introductionmentioning

confidence: 99%

Osteoclast-Like Giant Cell Reaction Associated With Cutaneous Squamous Cell Carcinoma: A Report of 2 Cases and Review of the Literature

Wooff

Werner²,

Murphy³

et al. 2009

The American Journal of Dermatopathology

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“…Cutaneous squamous cell carcinoma (SCC) associated with osteoclast‐like giant cells (osteoclastic cells) is very rare; only eight cases have been reported since 2006 . In the skin, stromal changes containing osteoclasts can occur in SCC, melanoma, basal cell carcinoma, nodular fasciitis, dermatofibroma, giant cell tumor of tendon sheath, giant cell malignant fibrous histiocytoma, atypical fibroxanthoma, phosphaturic mesenchymal tumor, soft tissue giant cell tumor of low malignant potential and pleomorphic dermal sarcoma.…”

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confidence: 99%

Squamous cell carcinoma with osteoclast‐like giant cells: a morphologically heterologous group including carcinosarcoma and squamous cell carcinoma with stromal changes

et al. 2015

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Cutaneous squamous cell carcinoma (SCC) with osteoclast-like giant cells (hereafter, osteoclastic cells) is very rare; eight cases have been reported since 2006. Whether the osteoclastic cells represents a reactive or neoplastic change remains a matter of debate. Osteoclastic cells are often observed in the sarcomatous component of cutaneous carcinosarcoma. SCC with osteoclastic cells is a heterogeneous condition that includes SCC with stromal changes containing osteoclastic cells (also known as osteoclast-like giant cell reaction) and carcinosarcoma. In some cases, SCC with an associated osteoclast-like giant cell reaction has been differentiated from carcinosarcoma based on the degree of cytologic atypia in non-epithelial components. We summarized the clinical and histopathologic characteristics of 11 patients of SCC with osteoclastic cells, including our two cases of SCC with an osteoclast-like giant cell reaction and one case of carcinosarcoma. The affected patients were old and more likely to be male (64%). Seven cases (64%) were in the head and neck. Moreover, multiple features of high risk SCC were observed, such as a tumor size greater than 2 cm (56%), moderate or poor differentiation (100%), recurrence (33%) and nodal metastasis (17%) after excision and immunosuppression (27%). Interestingly, half of the previously reported cases of SCC with osteoclastic giant cell reaction had histopathologic findings that were overlapping with those of carcinosarcoma.

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“…To the best of our knowledge, this is only the seventh reported case of squamous cell carcinoma with rhabdoid features (Table I). Of interest, all occurred in older male patients; patients also had a history of kidney failure and our patient was the second with history of multiple transplantations 5–9…”

Section: Discussionmentioning

confidence: 96%

“…Squamous cell carcinoma with rhabdoid features is an extremely rare variant of squamous cell carcinoma and has a high potential for aggressive behavior and a poor outcome. Although the diagnoses of such lesions have been documented in the surgical pathology literature,5–9 reports in the cytology literature however have not yet appeared. To the best of our knowledge, it is the first fine needle aspiration (FNA) cytology case report of this entity and the second case in a patient with two autologous organ transplantations 5–9.…”

mentioning

confidence: 99%

“…Although the diagnoses of such lesions have been documented in the surgical pathology literature,5–9 reports in the cytology literature however have not yet appeared. To the best of our knowledge, it is the first fine needle aspiration (FNA) cytology case report of this entity and the second case in a patient with two autologous organ transplantations 5–9. Our main goal in presenting such a rare entity is to share the challenges faced in the preliminary diagnosis of an FNA and how to develop reasonable diagnoses and utilize immunohistochemistry and clinical information to reach an accurate final diagnosis.…”

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confidence: 99%

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Squamous cell carcinoma with rhabdoid phenotype of skin/soft tissue in a transplant patient: An exceptional case and review of the literature

Allam-Nandyala

DeConti

Purohit

et al. 2011

Diagnostic Cytopathology

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Squamous cell carcinoma with rhabdoid features (SCCRF) is a very rare and unusual cutaneous tumor. Here, we report an extraordinary case diagnosed by fine needle aspiration biopsy, in a 66-year-old man, status post multiple organ transplantation. The patient presented with a large ulcerating fungating mass in his forearm that had all the light microscopic and immunohistochemical features of a SCCRF. Previously six cases of SCCRF phenotype diagnosed by surgical pathology have been reported. This is the first case diagnosed cytologically. A review of the literature with emphasis on the differential diagnoses of such unusual rhabdoid-like tumors in fine-needle aspiration biopsy and the potential molecular mechanism for rhabdoid phenotype in transplant patients are discussed.

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Squamous cell carcinoma with rhabdoid phenotype and osteoclast-like giant cells in a renal–pancreas transplant recipient

Cited by 14 publications

References 18 publications

Osteoclast-Like Giant Cell Reaction Associated With Cutaneous Squamous Cell Carcinoma: A Report of 2 Cases and Review of the Literature

Osteoclast-Like Giant Cell Reaction Associated With Cutaneous Squamous Cell Carcinoma: A Report of 2 Cases and Review of the Literature

Squamous cell carcinoma with osteoclast‐like giant cells: a morphologically heterologous group including carcinosarcoma and squamous cell carcinoma with stromal changes

Squamous cell carcinoma with rhabdoid phenotype of skin/soft tissue in a transplant patient: An exceptional case and review of the literature

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