Squamous cell carcinoma superimposed on necrobiosis lipoidica: a rare complication

Souza, Maria Emilia Vieira de; Recuero, Júlia Kanaan; Santos, M.P. dos; Bonamigo, Renan Rangel

doi:10.1016/j.abd.2020.03.014

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…NL is a rare granulomatous disease, which in very rare cases may degenerate into cSCC. A literature review by de Souza et al identified only 16 published cSCCs on top of NL [ 2 ]. Although when first described, NL was associated with diabetes mellitus (DM), the current literature shows no direct correlation between the two diseases.…”

Section: Discussionmentioning

confidence: 99%

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Lower leg reconstruction after resection of a squamous cell carcinoma on necrobiosis lipoidica with a pedicled fibula and an extended anterolateral thigh flap—a case report

et al. 2023

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Background Extensive loss of soft tissue and bone due to neoplasia, trauma, or infection in extremities often leads to amputation. Case presentation We present the case of a 72-year-old female patient presenting with an extended cutaneous squamous cell carcinoma of the lower leg, developed on top of necrobiosis lipoidica. After achieving the R0 resection, a 26 × 20-cm soft tissue and 15-cm tibial bone defect resulted. The contralateral leg had been lost due to the same disease 18 years before. We achieved a successful reconstruction of the leg using a pedicled fibula transplantation, an extended anterolateral thigh perforator flap, and an internal fixation with plate and screws. Two years after the original surgery, the patient is relapse-free and mobile, with adequate function of the reconstructed foot. Conclusions Our case presented a unique combination of pedicled fibula transplantation and free extended ALT perforator flap to reconstruct an extensive defect after resection of a rare cSCC on top of NL. In selected cases, the boundaries of limb salvage can be pushed far beyond the current standards of treatment.

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Section: Discussionmentioning

confidence: 99%

“…Necrobiosis lipoidica (NL) is a rare chronic idiopathic granulomatous disease that usually appears in the lower legs. The lesions have a tendency for ulceration and, in rare cases, a cSCC may develop on NL [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Lower leg reconstruction after resection of a squamous cell carcinoma on necrobiosis lipoidica with a pedicled fibula and an extended anterolateral thigh flap—a case report

et al. 2023

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Diabetes Mellitus

Schons

Beber²

2023

Dermatology in Public Health Environments

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Lower leg reconstruction after resection of a squamous cell carcinoma on necrobiosis lipoidica with a pedicled fibula and an extended anterolateral thigh flap – A case report

Bota

Meier

Garzarolli

et al. 2022

Preprint

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Background: Extensive loss of soft tissue and bone due to neoplasia, trauma or infection in extremities often lead to amputation. Case presentation: We present the case of a 72 year old female patient presenting with an extended cutaneous scquamous cell carcinoma of the lower leg, developed on top of necrobiosis lipoidica. After achieving the R0 resection, a 26X20 cm soft tissue and 15 cm tibial bone defect resulted. The contralateral leg had been lost due to the same disease 18 years before. We achieved a successfull reconstruction of the leg using a pedicled fibula transplantation, an extended anterolateral thigh perforator flap and an internal fixation with plate and screws. Two years after the original surgery the patient is relaps-free and mobile, with adequate function of the reconstructed foot. Conclusions: Our case presented a unique combination of pedicled fibula transplantation and free extended ALT perforator flap to reconstruct an extensive defect after resection of a rare cSCC on top of NL. In selected cases, the boundaries of limb salvage can be pushed far beyond the current standards of treatment.

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Squamous cell carcinoma superimposed on necrobiosis lipoidica: a rare complication

Cited by 4 publications

References 3 publications

Lower leg reconstruction after resection of a squamous cell carcinoma on necrobiosis lipoidica with a pedicled fibula and an extended anterolateral thigh flap—a case report

Lower leg reconstruction after resection of a squamous cell carcinoma on necrobiosis lipoidica with a pedicled fibula and an extended anterolateral thigh flap—a case report

Diabetes Mellitus

Lower leg reconstruction after resection of a squamous cell carcinoma on necrobiosis lipoidica with a pedicled fibula and an extended anterolateral thigh flap – A case report

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