Squamous cell carcinoma-related antigen in children with acute asthma

Nishi, Natsuko; Miyazaki, Michiko; Tsuji, Kosuke; Hitomi, Tomohiro; Muro, Eriko; Zaitsu, Masafumi; Yamamoto, Shintaro; Inada, Shigeyasu; Kobayashi, Ikuko; Ichimaru, Tomohiro; Izuhara, Kenji; Nagumo, Fumio; Yuyama, Noriko; Hamasaki, Yuhei

doi:10.1016/s1081-1206(10)60993-3

Cited by 25 publications

(21 citation statements)

References 18 publications

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“…Although Timp1 was reported to play a role in extracellular matrix remodeling, and its role in the development of allergic asthma is well described (30,31), the functional role of Serpina3n has not been established. In humans, SERPIN3A, commonly known as antichymotrypsin, is produced by a variety of cell types, including hepatocytes and bronchial epithelial cells during acute inflammatory responses, and studies showed that serum levels of two other serpin family members, SERPINB3 and SERPINB4, are elevated in patients with asthma (32,33). Interestingly, in a recent animal model of allergic asthma, the murine ortholog, Serpin3ba, was shown to mediate HDM-induced mucus production (34).…”

Section: Discussionmentioning

confidence: 99%

Shifting of Immune Responsiveness to House Dust Mite by Influenza A Infection: Genomic Insights

Al-Garawi

Husain

Ilieva

et al. 2012

The Journal of Immunology

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Respiratory viral infections have been associated with an increased incidence of allergic asthma. However, the mechanisms by which respiratory infections facilitate allergic airway disease are incompletely understood. We previously showed that exposure to a low dose of house dust mite (HDM) resulted in enhanced HDM-mediated allergic airway inflammation, and, importantly, marked airway hyperreactivity only when allergen exposure occurred during an acute influenza A infection. In this study, we evaluated the impact of concurrent influenza infection and allergen exposure at the genomic level, using whole-genome microarray. Our data showed that, in contrast to exposure to a low dose of HDM, influenza A infection led to a dramatic increase in gene expression, particularly of TLRs, C-type lectin receptors, several complement components, as well as FcεR1. Additionally, we observed increased expression of a number of genes encoding chemokines and cytokines associated with the recruitment of proinflammatory cells. Moreover, HDM exposure in the context of an influenza A infection resulted in the induction of unique genes, including calgranulin A (S100a8), an endogenous damage-associated molecular pattern and TLR4 agonist. In addition, we observed significantly increased expression of serum amyloid A (Saa3) and serine protease inhibitor 3n (Serpina3n). This study showed that influenza infection markedly increased the expression of multiple gene classes capable of sensing allergens and amplifying the ensuing immune-inflammatory response. We propose that influenza A infection primes the lung environment in such a way as to lower the threshold of allergen responsiveness, thus facilitating the emergence of a clinically significant allergic phenotype.

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Section: Discussionmentioning

confidence: 99%

Shifting of Immune Responsiveness to House Dust Mite by Influenza A Infection: Genomic Insights

Al-Garawi

Husain

Ilieva

et al. 2012

The Journal of Immunology

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“…SCCA is broadly expressed in the spinous and granular layers of the squamous epithelium and in several organs, including the uterine cervix, tongue, tonsil, esophagus, airways, and skin [4]. It has been reported that the serum level of SCCA was elevated in patients with atopic dermatitis [5], asthma [6], and psoriasis [7, 8], as well as in those with squamous cell carcinoma. The expression of SCCA was increased in both serum and skin in the psoriasis patients [9].…”

Section: Introductionmentioning

confidence: 99%

Serum Squamous Cell Carcinoma Antigen in Psoriasis: A Potential Quantitative Biomarker for Disease Severity

et al. 2018

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Background: An objective and quantitative method to evaluate psoriasis severity is important for practice and research in the precision care of psoriasis. Objectives: We aimed to explore serum biomarkers quantitatively in association with disease severity and treatment response in psoriasis patients, with serum squamous cell carcinoma antigen (SCCA) evaluated in this pilot study. Methods: 15 psoriasis patients were treated with adalimumab. At different visits before and after treatment, quantitative body surface area (qBSA) was obtained from standardized digital body images of the patients, and the psoriasis area severity index (PASI) was also monitored. SCCA were detected by using microparticle enzyme immunoassay. The serum biomarkers were also tested in healthy volunteers as normal controls. Receiver-operating characteristic (ROC) curve analysis was used to explore the optimal cutoff point of SCCA to differentiate mild and moderate-to-severe psoriasis. Results: The serum SCCA level in the psoriasis group was significantly higher (p < 0.05) than in the normal control group. After treatment, the serum SCCA levels were significantly decreased (p < 0.05). The SCCA level was well correlated with PASI and qBSA. In ROC analysis, when taking PASI = 10 or qBSA = 10% as the threshold, an optimal cutoff point of SCCA was found at 2.0 ng/mL with the highest Youden index. Conclusion: Serum SCCA might be a useful quantitative biomarker for psoriasis disease severity.

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“…Elevated SERPINB4 and B3 levels are detected in the serum of patients with atopic dermatitis 15 and asthma 16. Recent studies suggests the use of SERPINB4 and B3 as potential biomarkers for atopic dermatitis 17 and asthma 18. SERPINB4 and B3 expression is induced in bronchial epithelial cells treated with IL-4 and IL-13 19 in a STAT6-dependent fashion 20.…”

Section: Introductionmentioning

confidence: 99%

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma

Sivaprasad

Askew

Ericksen

et al. 2011

Journal of Allergy and Clinical Immunology

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Squamous cell carcinoma-related antigen in children with acute asthma

Cited by 25 publications

References 18 publications

Shifting of Immune Responsiveness to House Dust Mite by Influenza A Infection: Genomic Insights

Shifting of Immune Responsiveness to House Dust Mite by Influenza A Infection: Genomic Insights

Serum Squamous Cell Carcinoma Antigen in Psoriasis: A Potential Quantitative Biomarker for Disease Severity

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma

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