Squamous cell carcinoma of the pancreas

Sears, Henry F.; Kim, Young; Strawitz, Joseph G.

doi:10.1002/jso.2930140312

Cited by 29 publications

(23 citation statements)

References 5 publications

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“…It is our opinion that primary tumors of the pancreas that show any degree of definitive malignant squamous cell differentiation on routine sectioning should be considered adenosquamous carcinoma. Furthermore, it has been suggested in the medical literature that squamous cell carcinoma occurs de novo within the pancreas without an identifiable ductal component (16,(21)(22)(23). Based on our review of these publications, there was either limited diagnostic material or no resection specimen, or the cases were presented as part of a large series of pancreatic cancer, which did not specify the details of the individual cases.…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous Carcinoma Of The Pancreas: A Clinicopathologic Series Of 25 Cases

et al. 2001

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Background: Adenosquamous carcinoma is a rare aggressive subtype of pancreatic adenocarcinoma. We describe the clinical, pathologic, and molecular characteristics of 25 of these lesions, the largest series to date. Methods: Twenty-five cases of adenosquamous carcinoma of the pancreas diagnosed between 1961 and 1994 were retrieved from the files of the Endocrine Registry of the Armed Forces Institute of Pathology. Histologic features were reviewed, histochemical, immunohistochemical, and molecular (k-ras) studies were performed, and patient follow-up was obtained. Results: The patients included 17 men and eight women, aged 28 to 82 years (mean, 65.4 y). The patients usually experienced weight loss (n ‫؍‬ 17) or painless jaundice (n ‫؍‬ 11), while also presenting with other abdominal symptoms. The tumors affected the head most frequently (n ‫؍‬ 17), followed by the tail (n ‫؍‬ 9) or body (n ‫؍‬ 4). Five cases involved more than one anatomic region of the pancreas. Microscopically, all tumors demonstrated dual differentiation toward adenocarcinoma and squamous cell carcinoma. All cases tested were immunoreactive with keratin (AE1:AE3 and CK1), whereas other keratin markers were variably expressed: CK5/6 (88%), CK7 (68%), Cam5.2 (41%), and CK20(26%). CA-19 -9 (84%) and CEA (74%) were positive in the majority of the cases. K-ras oncogene mutations were identified in seven of 13 cases. All patients died from their disease an average of 5.8

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Section: Discussionmentioning

confidence: 99%

Adenosquamous Carcinoma Of The Pancreas: A Clinicopathologic Series Of 25 Cases

et al. 2001

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“…Mikal and Campbell, as quoted by Sears et al, reported pancreatitis in 49 of 100 autopsied cases with pancreatic carcinoma, and Gambill, as quoted by Sears et al, showed significant pancreatitis by histologic criterion in 26 of 225 patients with pancreatic and ampullary carcinoma 1 . These pathology studies suggest that chronic pancreatitis may be associated with pancreatic carcinoma, but they could not specifically evaluate whether the malignant changes developed from the inflammatory lesions 1 .…”

Section: Figure 1 Hepatic Biopsy Showing Normal Liver In Lower Quadramentioning

confidence: 96%

“…A number of investigators have found that the combination of pancreatic calcification and chronic pancreatitis is associated with pancreatic cancer. Currently, no evidence supports a cause-effect relationship between pancreatitis and carcinoma 1 .…”

Section: Figure 1 Hepatic Biopsy Showing Normal Liver In Lower Quadramentioning

confidence: 99%

“…Within the various studies, the median survival was generally poor, with 1-year and 5-year survival rates of 4.8% and 1% respectively 3,[11][12][13]19 . Two reports showed a similar mean survival for the two histologically different pancreatic tumour types, but it would appear that prognosis for the squamous cell type may be worse than that of the usual adenocarcinoma of the pancreas [1][2][3][11][12][13]19 .…”

Section: Figure 1 Hepatic Biopsy Showing Normal Liver In Lower Quadramentioning

confidence: 99%

“…In one of the theories noted earlier, pancreatic squamous cell carcinoma has been postulated to arise from ductules that have undergone squamous metaplasia secondary to chronic inflammation 3 , and most, if not all, instances of pancreatic squamous cell carcinoma are associated with chronic pancreatitis 1 . Mikal and Campbell, as quoted by Sears et al, reported pancreatitis in 49 of 100 autopsied cases with pancreatic carcinoma, and Gambill, as quoted by Sears et al, showed significant pancreatitis by histologic criterion in 26 of 225 patients with pancreatic and ampullary carcinoma 1 . These pathology studies suggest that chronic pancreatitis may be associated with pancreatic carcinoma, but they could not specifically evaluate whether the malignant changes developed from the inflammatory lesions 1 .…”

Section: Figure 1 Hepatic Biopsy Showing Normal Liver In Lower Quadramentioning

confidence: 99%

See 2 more Smart Citations

Squamous Cell Carcinoma of the Pancreas

Alshehri¹,

Silverman²,

King³

2008

Current Oncology

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Pancreatic malignancies can be subdivided into endocrine and non-endocrine processes. Of the non-endocrine tumours, ductal carcinoma is the most common, and the ductal carcinomas can be further subdivided into adenocarcinomas and squamous cell carcinomas. The adenocarcinomas constitute most of the non-endocrine pancreatic malignancies, and the treatment options for these, although limited in efficacy, are relatively well established. The squamous cell carcinoma pathology is a rare entity, and few reports of it are found in the literature. As a result, treatment options for squamous cell carcinoma of the pancreas are poorly understood. Here, we report the presentation of a 48-year-old woman with metastatic squamous cell carcinoma of the pancreas. The subsequent investigations, treatment, and outcome are described.

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