Squamous Cell Carcinoma of the Floor of the Mouth: Tumour Thickness and the Rate of Cervical Metastasis

Abstract

Tumour thickness has been shown to be directly related to rates of cervical lymph node metastasis in floor of mouth SCC. The primary tumour thickness associated with significantly increased rates of metastasis is similar to that shown in previous studies examining SCC of the oral tongue.

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

“…However, appropriate validation is lacking, and the same indicators (depth of invasion) should be compared. Suzuki, and Wallwork, studied patients with T1/T2 floor of mouth SCC, however these studies are suboptimal as they included patients with clinically positive lymph nodes which possibly could skew significant cut-off values [8,9]. [10].…”

Nodal involvement and p16-staining in upper alveolar ridge and hard palate cancer

“…This poor prognosis could reflect higher prevalence of neck node involvement at diagnosis or higher prevalence of poor prognotic factors like p16-negative status [1] . The incidence of neck metastasis has been extensively described in cancer of the tongue and floor of the mouth (20% to 30%) and has been assigned a significant prognostic role in patients with clinically nodenegative disease [20,21] . Clinicopathologic factors like large tumor size, tumor depth, higher grade, and microvascular invasion have been associated with the development of cervical lymph node metastasis in oral SCC [21] .…”

“…The incidence of neck metastasis has been extensively described in cancer of the tongue and floor of the mouth (20% to 30%) and has been assigned a significant prognostic role in patients with clinically nodenegative disease [20,21] . Clinicopathologic factors like large tumor size, tumor depth, higher grade, and microvascular invasion have been associated with the development of cervical lymph node metastasis in oral SCC [21] . Elective treatment of the neck with staging neck dissection is generally carried out in patients with SCC of the oral cavity when the risk of clinically occult metastases exceeds 15% to 20%, and treatment of the clinically N0 neck is now accepted for certain oral cavity subsites, such as the tongue and floor of mouth, where elective neck dissection produces a survival advantage [22][23][24][25][26] .…”

Metastasis of Head and Neck Squamous Cell Carcinoma

“…Clinicopathologic factors associated with the development of cervical lymph node metastasis have been well studied for other locations like tongue, mouth floor, and cheek, in particular concerning tumor size (in tongue carcinoma≥3 mm), tumor depth (≥4 mm in tongue carcinoma), differentiation, mode of invasion, microvascular invasion, and histologic grade of malignancy (Kurokawa, et al, 2002, Sparano, et al, 2004, Wallwork, et al, 2007. The presence or absence of lymph node metastasis is a major prognostic factor for survival in patients with negative cervical lymph nodes (Hiratsuka, et al, 1997).…”

“…The presence or absence of lymph node metastasis is a major prognostic factor for survival in patients with negative cervical lymph nodes (Hiratsuka, et al, 1997). A high incidence (20-30%) of cervical metastasis of cancer in the tongue/mouth floor has been well studied (Kurokawa, et al, 2002, Sparano, et al, 2004, Wallwork, et al, 2007. But very few studies have been performed concerning squamous cell carcinoma of the maxilla (Simental, et al, 2006).…”