Squamous cell carcinoma of the bladder: a patient treated successfully with a new combined chemotherapy regimen, intraarterial nedaplatin and pirarubicin plus intravenous methotrexate and vincristine

Abstract

We report a case of squamous cell carcinoma (SCC) of the bladder treated successfully with intraarterial chemotherapy using nedaplatin. A 75-year-old woman was admitted to our hospital in March 2004 with gross hematuria. Cystoscopic examination showed tumors on the anterior bladder wall. Computed tomography (CT) scans and magnetic resonance imaging (MRI) revealed extravesical invasion of the tumors, and a clinical diagnosis of T3bN0M0 was made. Transurethral biopsy was performed, and histopathological examination revealed SCC, grade 2-3, invasive. The patient received a new combined chemotherapy, intraarterial nedaplatin and pirarubicin plus intravenous methotrexate and vincristine. After two courses of the chemotherapy, CT scans and MRI demonstrated no tumor in the bladder. Transurethral bladder-wall biopsy was performed in November 2004, and histopathological examination of the specimen revealed no definite tumors. The patient is alive without evidence of disease more than 1 year after the chemotherapy.

The changing patterns of bladder cancer in Egypt over the past 26 years

“…Conversely, SCC associated with schistosomal infection has an aggressive progression rate and is associated with the chronic inflammatory process that occurs during infection [40,41]. At first diagnosis, patients presenting with SCC associated with schistosomal infection have locally advanced tumors and a mean age, that is, generally 10-20 years younger than that of patients with non-schistosomal bladder cancer, indicating the rapid development of this type, irrespective of the aging of the general population [42].…”