Squamous Cell Carcinoma of the Vagina: A Review of 70 Cases

Dixit, Sanjay; Singhal, Surinder K; Baboo, H. A.

doi:10.1006/gyno.1993.1013

Cited by 64 publications

(35 citation statements)

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“…49 External irradiation alone yielded poor results, as expected. 49 External irradiation alone yielded poor results, as expected.…”

Section: Discussionsupporting

confidence: 66%

“…For example, in 1979, Pride et al 41 observed that the survival rate from invasive squamous cell carcinoma of the vagina had improved significantly over the past 25 years and suggested that this was due to the widespread use of interstitial irradiation of the local vaginal tumor and administration of supravoltage radiation. [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] Series selected for tabulation in the latter table were those in which a minimum of 25 patients had been treated with radiotherapy for primary vaginal carcinoma (data from the current study are entered on the last line of Table 7). [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] Series selected for tabulation in the latter table were those in which a minimum of 25 patients had been treated with radiotherapy for primary vaginal carcinoma (data from the current study are entered on the last line of Table 7).…”

Section: Discussionmentioning

confidence: 99%

“…The treatment-related severe morbidity rates ranged from 6.4% to 22.4% (Table 7), [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] with our own study group observing a 12.7% incidence rate for severe radiotoxicity, which includes one treatment-related death. The complication rates recorded by the three groups in which intracavitary devices were used exclusively have ranged from a respectable 6.4% to an unsatisfactory 18%.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Primary invasive carcinoma of the vagina

Tewari

Cappuccini

Puthawala

et al. 2001

Cancer

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The large strain behavior of a glassy polymer was studied in terms of compression tests at various rates, while the local deformation was evaluated with a noncontact laser extensometer. The main features of yield and postyielding were described with a constitutive model from nonlinear viscoelasticity, combined with a kinematic formulation for the separation of total deformation into a viscoelastic and a plastic part, respectively. The concept of plastic shear transformations introduced elsewhere was used to develop a mathematical model for the rate of plastic deformation. The entire experimental true stress–strain curves (including strain hardening and strain softening) could, through this model, be identified in a self‐consistent manner. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 79: 2534–2542, 2001

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“…49 External irradiation alone yielded poor results, as expected. 49 External irradiation alone yielded poor results, as expected.…”

Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary invasive carcinoma of the vagina

Tewari

Cappuccini

Puthawala

et al. 2001

Cancer

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“…Tarraza et al [10] reported that upper-third lesions developed local recurrences more frequently, but lower-third lesions developed a relatively high number of sidewall and distant recurrences. Lesions to the posterior wall have a worse prognosis than those involving other vaginal walls [11,12]. If the cancer is in the upper vagina, it may be treated by a radical hysterectomy, bilateral radical pelvic lymph node removal, or radical or partial vaginectomy.…”

Section: Discussionmentioning

confidence: 99%

Uterine Prolapse Complicated by Vaginal Cancer: A Case Report and Literature Review

Wang¹,

Li²,

et al. 2014

Gynecol Obstet Invest

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Primary vaginal cancer is not common, representing 1-2% of all female genital malignancies. We present a case of a third-degree uterine prolapse complicated by an isolated primary vaginal cancer and its surgical treatment. The cervix was clinically normal, but on the nearby prolapsed vaginal wall, a large exogenous hard lesion had developed. A biopsy of the lesion revealed a squamous carcinoma. The patient was asymptomatic and had no recurrence during the last 4 years of follow-up after surgical treatment with radiotherapy. The surgical treatment with or without radiotherapy is the optimum treatment for uterine prolapse with early-stage vaginal squamous cell carcinoma, although the majority of vaginal malignancies are treated with radiotherapy. We recommend always performing a biopsy prior to surgery in prolapse-induced ulceration.

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“…Most SCCVa begin as a precancerous vaginal intraepithelial neoplasia (VaIN), which can be detected as an abnormality on a pap smear and confirmed by a colposcopy [6]. VaIN and primary vaginal cancer are often asymptomatic until the tumor reaches an advanced stage: only 25% of cases are diagnosed at stage I or II, while the rest are diagnosed at stage III or IV [7]. Treatments for VAIN include laser ablation and topical therapy, neither of which are effective against an invasive tumor [6].…”

Section: Introductionmentioning

confidence: 99%

Prevention of K-Ras- and Pten-mediated intravaginal tumors by treatment with camptothecin-loaded PLGA nanoparticles

Blum

Weller

Booth

et al. 2011

Drug Deliv. and Transl. Res.

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Primary squamous cell carcinoma of the vagina is an uncommon disease that often exhibits few symptoms before reaching an advanced stage. Topical intravaginal therapies for resolving precancerous and cancerous vaginal lesions have the potential to be non-invasive and safer alternatives to existing treatment options. Two factors limit the testing of this approach: lack of a preclinical intravaginal tumor model and absence of safe and effective topical delivery systems. In this study, we present both an inducible genetic model of vaginal squamous cell carcinoma in mice and a novel topical delivery system. Tumors were generated via activation of oncogenic K-Ras and inactivation of tumor suppressor Pten in LSL-K-RasG12D/+ PtenloxP/loxP mice. This was accomplished by exposing the vaginal epithelium to a recombinant adenoviral vector expressing Cre recombinase (AdCre). As early as 3 weeks after AdCre exposure exophytic masses protruding from the vagina were observed; these were confirmed to be squamous cell carcinoma by histology. We utilized this model to investigate an anticancer therapy based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with camptothecin (CPT); our earlier work has shown that PLGA nanoparticles can penetrate the vaginal epithelium and provide sustained CPT release. Particles were lavaged into the vaginal cavity of AdCre-infected mice. None of the mice receiving CPT nanoparticles developed tumors. These results demonstrate a novel topical strategy to resolve precancerous and cancerous lesions in the female reproductive tract.

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Squamous Cell Carcinoma of the Vagina: A Review of 70 Cases

Cited by 64 publications

References 0 publications

Primary invasive carcinoma of the vagina

Primary invasive carcinoma of the vagina

Uterine Prolapse Complicated by Vaginal Cancer: A Case Report and Literature Review

Prevention of K-Ras- and Pten-mediated intravaginal tumors by treatment with camptothecin-loaded PLGA nanoparticles

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