Squamous cell carcinoma of the temporal bone

Abstract

A lateral temporal bone resection is adequate treatment for T1 and T2 tumours. Post-operative radiotherapy should probably be offered for large T2 tumours. For T3 and T4 tumours, a subtotal petrosectomy with parotidectomy followed by post-operative radiotherapy is adequate treatment, as it offers a similar outcome to that of more extensive procedures.

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

“…The extant literature consists of numerous case series that have reported a wide range of survival data, reflecting differences in the underlying characteristics of cohorts drawn from various institutions. 1,6,[8][9][10][12][13][14][15]18,19,22,24,[30][31][32][33][34][35][36][37][38][39][40][41] Historical survival data can be most readily generalized to clinical practice if factors predictive of outcome can be identified. Several larger series have reported preliminary descriptions of factors influencing survival, based on univariate comparisons.…”

“…These numbers are reflections of the underlying characteristics of the patient cohort at each institution. [8][9][10][11][12][13][14][15][17][18][19]22,23,[30][31][32]34,35,[37][38][39][40][41][42] Attempting to improve understanding of prognostic factors, 5 groups have recently analyzed outcomes using univariate analyses. In 1997, Testa et al 20 Based on these outcomes data, we currently consider the minimum operation for the vast majority of malignant disease involving the external auditory canal/temporal bone to be a lateral temporal bone resection.…”

“…Most cohorts have been limited to squamous cell histology, and comprehensive outcomes analyses have been limited. 2,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Further complicating analysis, there is no recognized American Joint Committee on Cancer (AJCC) or Union Internationale Contre le Cancer (UICC) staging system for tumors of the external auditory canal/temporal bone, with multiple systems having been proposed. 3,16,25,26 To date, the most widely used system is the University of Pittsburgh staging system, first described in 1990 by Arriaga and colleagues 25 and modified in 2000 by Moody et al 3 Other than Pittsburgh stage and surgical margin status, no other factors have been consistently demonstrated to be associated with outcome, and multivariable analyses of factors affecting outcome have not been reported.…”

Bilateral carcinoma of the temporal bone: Case report and literature review

“…In a review of all English-language publications addressing the surgical management of squamous cell carcinoma of the temporal bone, Prasad and Janecka (1994) found that patients with tumours restricted to the external auditory canal had an overall 5-year survival rate of approximately 50%, while Bibas et al (2008) demonstrated a disease-specific overall five-year survival of 64%. Patients with lesions that extended into the middle ear space had an overall 5-year survival rate of approximately 25%, and patients with more aggressive tumours including those with petrous apex, internal carotid artery, or dural or temporal lobe involvement had a 5-year survival rate of approximately 6%.…”

“…An incidence of 1 to 6 cases per million has been reported in the literature (Kinney, 1999;Barrs, 2001). There are 14 reports of bilateral squamous cell carcinoma published in the literature (Juby, 1957;Lederman, 1965;Hakata et al, 1976;Brookes, 1982;Milford and Violaris, 1987;Snyman and Claasen, 1988;Fontanel et al, 1989;Munk-Nielsen and Hansen, 1991;Kuhel et al, 1996;Knegt et al, 2002;Wolfe et al, 2002;Thevarajah et al, 2005;Shagdarsuren et al, 2006;Elsürer et al, 2007;Bibas et al, 2008). The clinical manifestations include a mass in the external auditory canal (EAC) or middle ear with or without otorrhoea, hearing impairment, facial palsy, vertigo and tinnitus (Manolidis et al, 1998;Moffat, 2003).…”