Squamous cell carcinoma of the ascending colon: two cases

Abstract

Squamous cell carcinoma (SCC) of the colon without known primary source is a rare finding that needs aggressive management. We report two cases of SCC of the colon without any clear extra-colonic source despite extensive workup. In our experience, the clinical course and prognosis are largely dependent on the presence of metastatic disease at diagnosis. The main treatment is surgery, with chemotherapy having less defined role.

Mixed neuroendocrine and squamous cell carcinoma of the colon: A case report and literature review

“…SCC has an occurrence of 0.1-0.25% of cases of colorectal carcinoma [4]. SCC of the colon has less than 100 cases reported in the literature [5]. The pathogenesis of SCC is unclear, and a commonly reported theory suggests that multipotent cells differentiate into squamous cells from mucosal injury [2,5].…”

“…SCC of the colon has less than 100 cases reported in the literature [5]. The pathogenesis of SCC is unclear, and a commonly reported theory suggests that multipotent cells differentiate into squamous cells from mucosal injury [2,5]. SCC has been seen more commonly in the colon as “pure” squamous cells [6], but rarely is SCC seen as mixed with another epithelium carcinoma.…”

Undiagnosed metastatic ileocecal carcinoma: a rare aetiology for Fournier gangrene

“…5 Several predisposing conditions have been identified which create a favourable micro-environment that promotes the spread of the infection. 6 Malignancy, including occult colorectal malignancy, has been identified as a comorbid condition, and has been associated with higher death rate. 7 Although occult colorectal carcinoma has been documented several times as an aetiology, ileocecal carcinoma has never been as far as our literature search.…”

“…Neisseria gonorrhoeae and Chlamydia trachomatis are major causes of PID; other organisms of Enterobacteriaceae, such as E. coli, are often isolated from individuals with TOA. 6 Escherichia coli infection may result in gas formation for a TOA patient with diabetes. 4 Although the patient in the current case did not have diabetes, this result, in which E. coli was isolated, did not contradict TOA.…”

Metastatic squamous cell carcinoma presenting as an ileocolonic fistula

“…A primary SCC of the bowel is very uncommon. Less than 0.25% of all colon carcinomas are of SCC origin 6 . The initial histological specimen showed that the SCC was originating from the fistulous tract rather than the bowel mucosa also makes this less likely.…”