Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report

Dabek, Robert J; Bizanti, Anas; Thomas, Samantha; Kalla, Abhishek; Hamdallah, Isam

doi:10.7759/cureus.10739

Cited by 2 publications

(3 citation statements)

References 17 publications

(18 reference statements)

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“…GIP signals associated with ICIs were detected by using the VigiBase database that confirmed our research (47). More and more studies reported cases of GIP after taking PD-1 (48,49). Therefore, these signals need to be paid more attention.…”

Section: Journal Of Pharmacy and Pharmaceutical Sciencessupporting

confidence: 80%

Gastrointestinal perforation associated with novel antineoplastic agents: A real-world study based on the FDA Adverse Event Reporting System

Yu¹,

Zhu²,

Chen³

et al. 2023

J. pharm. pharm. sci.

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Purpose: Gastrointestinal perforation (GIP) is a fatal adverse event (AE). The AE of GIP induced by novel antineoplastic agents has attracted attention recently. We aimed to explore the AE signals of GIP related to novel antineoplastic agents comprehensively based on the FDA Adverse Event Reporting System (FAERS).Methods: The FAERS database containing 71 quarters of records was used for analysis. Reporting odds ratio (ROR), information component (IC), and empirical Bayesian geometric mean (EBGM) were utilized to evaluate the signals of GIP associated with novel antineoplastic drugs. Standardization of drug names was by employing MedEx-UIMA software and Python. Data analysis and visualization were performed using MySQL Workbench and R software.Results: After cleaning and handling the data, 5226 GIP cases were identified that were associated with new antineoplastic medications, where these agents were the main suspected contributors. A total of 37 novel antineoplastic drugs were detected with signals of GIP for ROR and IC. Only 22 drugs showed statistically significant signals for EBGM. We found the GIP signals of 22 novel antineoplastic drugs overlapped for the 3 indicators, including anti-vascular endothelial growth factor/vascular endothelial growth factor receptor, anti-endothelial growth factor receptor, immune checkpoint inhibitors, and so on.Conclusion: The potential risk of GIP associated with several novel antineoplastic agents was identified through data mining, which provided valuable information on the safety risks associated with GIP among these drugs. The potential threat of GIP should be recognized and managed properly when using these novel antineoplastic agents.

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Section: Journal Of Pharmacy and Pharmaceutical Sciencessupporting

confidence: 80%

Gastrointestinal perforation associated with novel antineoplastic agents: A real-world study based on the FDA Adverse Event Reporting System

Yu¹,

Zhu²,

Chen³

et al. 2023

J. pharm. pharm. sci.

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“…13 Metastases present primarily as obstructions but can also present as ileus, hemorrhage, bowel perforation, melena, and obstructive jaundice. [2][3][4][5][6][7][8][9][10][11]14 The initial evaluation of small bowel metastasis starts with CTs, magnetic resonance imagings, or PET scans. 3 Diagnosis is confirmed by obtaining pathology from upper endoscopy, enteroscopy, or exploratory laparotomy.…”

Section: Discussionmentioning

confidence: 99%

“…To date, there have been approximately 22 reported cases of head and neck cancers with metastasis to the bowel. [2][3][4][5][6][7][8][9][10][11]…”

Section: Introductionmentioning

confidence: 99%

Metastatic Head and Neck Squamous Cell Carcinoma Masquerading as Crohn's Disease

2022

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Metastasis from head and neck tumors to the small intestine is an extremely rare occurrence with a dismal prognosis. We present a 67-year-old man with metastatic head and neck squamous cell carcinoma that initially presented as recurrent small bowel obstruction and was misdiagnosed as Crohn's disease. On colonoscopy, terminal ileum biopsies of lymphoid-appearing subcentimeter nodules were positive for metastatic squamous cell cancer. Our case highlights the importance of having a high index of suspicion for metastasis in patients with a recent history of head and neck cancers.

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Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report

Cited by 2 publications

References 17 publications

Gastrointestinal perforation associated with novel antineoplastic agents: A real-world study based on the FDA Adverse Event Reporting System

Gastrointestinal perforation associated with novel antineoplastic agents: A real-world study based on the FDA Adverse Event Reporting System

Metastatic Head and Neck Squamous Cell Carcinoma Masquerading as Crohn's Disease

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