Squamous cell carcinoma of the lacrimal sac

Katircioğlu, Yasemin Arslan; Altiparmak, Uğur; Akmansu, Halit; Üstün, Hüseyin; Zorlu, Faruk; Duman, Sunay

doi:10.1076/orbi.22.3.151.15616

Cited by 13 publications

(4 citation statements)

References 1 publication

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“…In a clinical study, malignant tumors often present with rapid growth of the lacrimal sac tumor, fixation to the skin, and a firm consistency with irregular borders. Secondary malignant tumors often invade the lacrimal drainage system, causing the same symptoms of LDS tumors in addition to the symptoms of their primary tumors [20-22]. In our study, common presenting features were epiphora (60%), a palpable mass in the lacrimal sac area (100%), and painful swelling (30%).…”

Section: Discussionmentioning

confidence: 61%

“…Open biopsy was the preferred biopsy technique rather than FNAB in this study. Incisional biopsy is helpful for suspicious lacrimal sac tumors [22, 36, 37, 42-44, 46, 47]. Immunohistochemical analysis is important to confirm malignant cases.…”

Section: Discussionmentioning

confidence: 99%

“…Adjuvant treatment modalities include EBRT, local radiation therapy (plaque brachytherapy), and chemotherapy (CHOP regimen) or immunotherapy [22, 24]. In this study, adjuvant EBRT was administered in 5 (62.5%) cases of lacrimal sac tumors, especially in epithelial lacrimal sac carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Lacrimal Sac Tumors: A Case Series

Kadir¹,

Rashid²,

Sultana³

et al. 2021

Ocul Oncol Pathol

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Objective: The aim of the study was to describe the clinical presentation, management strategies, and outcomes in a case series of primary lacrimal sac tumors. Methods: This retrospective study was conducted in Sheikh Fajilatunnessa Mujib Eye Hospital and Training Institute, Bangladesh, from July 1 to December 31, 2020, and included all patients who were evaluated, treated, and followed up for at least 6 months from January 2013 to October 2020. One patient developed a recurrence of the adenocarcinoma of the lacrimal sac after 1 year of primary treatment. Patients’ demographic data were analyzed and reviewed from published articles on lacrimal sac tumors. We assessed patients clinically, followed by radiological evaluation. We also analyzed the biopsy technique, treatment modality, and recurrence. An oncologist reviewed all patients to prepare a plan for adjuvant treatment. Results: Ten patients with lacrimal sac tumors were included in this study. Swelling in the medial canthal region was the most common presenting feature (100%), followed by epiphora (60%) and pain (30%). Open biopsy was preferred over fine-needle aspiration biopsy. Incisional biopsy or complete excisional biopsy was performed for all suspected malignancies. Malignant tumors were found in 7 (70%) cases, and benign tumors in 3 (30%) cases. Non-Hodgkin’s lymphoma (NHL) (40%) was the most common malignant lacrimal sac tumor. Mucosa-associated lymphoid tissue lymphoma was 75%, and diffuse large B-cell lymphoma was 25% among the cases of NHL. Patients with epithelial malignancy were treated with external beam radiation therapy, while NHL patients were treated with chemotherapy (CHOP regimen). Recurrence was noted in 1 case (10%) of epithelial malignancy after 1 year of treatment. Conclusion: Successful management of lacrimal sac tumors requires a high index of suspicion, as these are fatal tumors, often misdiagnosed as dacryocystitis. Nonepithelial malignancies are more predominant than epithelial malignancies, and hematolymphoid tumors are most frequent.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lacrimal Sac Tumors: A Case Series

Kadir¹,

Rashid²,

Sultana³

et al. 2021

Ocul Oncol Pathol

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“…1 SCC classically presents with the non-specific symptom of tearing plus the clinical sign of lacrimal swelling, and is often initially misdiagnosed as chronic dacryocystitis. 2 Suspicion should arise if there are bloody tears or discharge, with or without epistaxis, or swelling that extends above the medial canthal tendon.…”

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confidence: 99%

Lacrimal sac primary squamous cell carcinoma with synchronous tonsillar primary squamous cell carcinoma

Lin

Philpott

Sisson

et al. 2019

Orbit

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Effectiveness of Nasolacrimal SCC Treatments and Promising Role of Chemo‐Induction: A Case Report and Systematic Review

Alsavaf,

Abouammo,

Bhuskute

et al. 2024

The Laryngoscope

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ObjectiveTo comprehensively analyze reported cases of nasolacrimal squamous cell carcinoma (NLSCC), focusing on risk factors, treatment modalities, and outcomes. Additionally, investigate the impact of human Papillomavirus (HPV) status and histopathological subtypes' impact on prognosis.Data SourcesPubmed, Embase.Review MethodsWe conducted a systematic literature review to identify relevant studies reporting cases of NLSCC. The review methods adhered to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. The final update was performed on May 31, 2023.ResultsThe 72 studies included a total of 313 participants (mean age: 55; 60% male). Longer symptom duration (44.1 ± 59.2 months) correlated with recurrence (p = 0.004), and males exhibited higher mortality rates (19.6% vs. 2.4% in females, p = 0.01). The overall survival (OS) rate among all patients was 87.1%. Basaloid NLSCC had a worse death outcome (p ≤ 0.001). HPV‐positive cases showed comparable OS, recurrence, and metastasis rates to the general population (p = 0.917, 0.851, 0.07, respectively). Comparing treatment approaches (surgery, surgery with adjuvant radiation, chemoradiotherapy [CRT] followed by surgery), no significant differences in 5 and 10‐year OS rates or recurrence were observed (p = 0.4, 0.24, respectively), but 5‐year metastasis events were significant (p = 0.024). Eye exenteration rates were 31.1%, 20%, and 0% for the respective treatments (p = 0.089). Induction chemotherapy saved four cases from potential exenteration with favorable prognosis.ConclusionEarly detection and diagnosis are of utmost importance in the management of NLSCC. Regardless of the treatment approach, HPV‐related NLSCC demonstrated similar outcomes to the general population. Basaloid histology represents the worst subtype in terms of prognosis. Limited adjuvant CRT cases showed improved outcomes and induction chemotherapy's importance was emphasized in recent literature and our shared experience. Laryngoscope, 2024

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Squamous cell carcinoma of the lacrimal sac

Abstract: The clinical and histopathological findings in a 40-year-old man with a lacrimal sac tumor are reported. Although the clinical history indicated a lacrimal sac obstruction and recurrent dacryocystitis, the lesion was diagnosed by light microscopy as a squamous cell carcinoma.

Cited by 13 publications

References 1 publication

Lacrimal Sac Tumors: A Case Series

Lacrimal Sac Tumors: A Case Series

Lacrimal sac primary squamous cell carcinoma with synchronous tonsillar primary squamous cell carcinoma

Effectiveness of Nasolacrimal SCC Treatments and Promising Role of Chemo‐Induction: A Case Report and Systematic Review

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