Squamous Cell Carcinoma of the Temporal Bone

Abstract

Although the survival figures in this series are comparable with the best outcomes from other units, our experience would suggest improvements can still be achieved by reconsidering the selection of patients for neck dissection and temperomandibular joint excision in early stage disease. We also conclude that postoperative radiotherapy should be delivered to all patients, including surgical salvage cases who may have received previous irradiation. Finally, the minority of patients with poor prognostic features should be offered a more palliative therapeutic approach.

Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal are associated with shorter survival

“…The TNM stages for a majority of tumors was stage IV [25 (54.3 %)]. The proportion of distant metastasis was low (4.3 %), similar to that reported in previous studies (Moffat et al 2000 ; Moody et al 2000 ; Nakagawa et al 2006 ; Bacciu et al 2013 ; Prasad et al 2014 ; Masterson et al 2014 ). The proportion of patients in which the cancer had spread to the lymph nodes was 21.7 %, slightly higher than that in previous studies (ranging from 10 to 15 %) (Moffat et al 2000 ).…”

“…Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is an aggressive malignancy with a poor prognosis. The reported incidence is less than six cases per million per year, accounting for 0.2 % of all tumors of the head and neck, with a reported 5-year disease-specific survival ranging from 19 to 48 % (Moffat et al 2000 ; Bacciu et al 2013 ; Prasad et al 2014 ; Masterson et al 2014 ). Because of the rarity of this tumor, it has been difficult for any single institution to analyze the clinical data and formulate an optimal evaluation and treatment strategy.…”

“…Because of the rarity of this tumor, it has been difficult for any single institution to analyze the clinical data and formulate an optimal evaluation and treatment strategy. Another impediment to the study of SCC of the EAC is the lack of a universally accepted staging system (Bacciu et al 2013 ; Prasad et al 2014 ; Masterson et al 2014 ; Nakagawa et al 2006 ). Currently, there is no recognized stand-alone American Joint Committee on Cancer (Chicago, IL, USA) or International Union Against Cancer (Geneva, Switzerland) staging system for SCC of the EAC (Prasad et al 2014 ).…”

“…A revised University of Pittsburgh (Pittsburg, PA, USA) staging system was proposed in the year 2000 (Moody et al 2000 ). This system is the classification tool that is commonly used for prognosis and treatment decisions in patients with SCC of the EAC (Bacciu et al 2013 ; Prasad et al 2014 ; Masterson et al 2014 ; Nakagawa et al 2006 ; Moody et al 2000 ). However, this tool does not correctly classify every patient (Prasad et al 2014 ; Mazzoni et al 2014 ); although the number is small, there are some patients with tumors that recur locally despite their categorization as low-risk and, conversely, patients with longer survival times despite their categorization as high-risk, based on the TNM system (Prasad et al 2014 ).…”

Clear cell variant squamous cell carcinoma of temporal bone: Case report and literature review

“…SCC affecting the temporal bone region is an aggressive malignancy with a poor prognosis. The reported incidence is less than 6 cases per million per year, which represents 0.3% of all head and neck cancers with 5-year disease-specific survival reported as ranging from 19% to 48% [ 1 , 4 , 5 ]. The reason for the aggressiveness of this malignancy might be found in the biological behavior of the disease, but also in the various potential routes of diffusion to the surrounding structures.…”