Squamous cell carcinoma of the superior gingival–buccal complex

Pathak, Kumar Alok; Mathur, Navneet; Talole, Sanjay; Deshpande, Mandar; Chaturvedi, Pankaj; Pai, Prathamesh; Chaukar, Devendra; D’Cruz, Anil

doi:10.1016/j.oraloncology.2006.09.009

Cited by 32 publications

(24 citation statements)

References 5 publications

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“…Thirty patients underwent resection of either the mandible or the maxilla and in the univariate model we identified composite resection as a positive prognostic factor. Pathak et al (14) reported that involvement of the maxillary bone was a prognostic factor affecting disease-free survival. Ghoshal et al (2) concluded that most locoregional recurrences of buccal SCC occurred within the first 2 years.…”

Section: Discussionmentioning

confidence: 99%

“…The authors suggested that in the case of a poorly differentiated carcinoma, an effective systemic treatment was required in order to achieve a better outcome. Pathak et al (14) demonstrated that the degree of tumor differentiation was a prognostic factor affecting the disease-free survival. However, Fang et al (10) assessed the prognostic factors on locoregional control of buccal SCC and reported that histological grading was of no prognostic value.…”

Section: Discussionmentioning

confidence: 99%

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Squamous cell carcinoma of the buccal mucosa: Analysis of clinical presentation, outcome and prognostic factors

Fang

Shi

et al. 2013

Molecular and Clinical Oncology

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Abstract. Squamous cell carcinoma (SCC) of the buccal mucosa is a common malignancy in Southeast Asia. The purpose of this study was to present our clinical experience with buccal SCC over a period of 7 years and to analyze the factors associated with surgical outcome. We conducted a retrospective review on 67 buccal SCC patients (between September, 2005 and May, 2011) with tumors restricted to or originating from the buccal mucosa. In a univariate model, nodal stage, degree of tumor differentiation and composite resection were associated with recurrence, while in a multivariate model, the degree of differentiation was the only factor affecting locoregional control. In a survival analysis, recurrence, nodal stage and degree of differentiation were considered as significant factors. Buccal SCC is an aggressive malignant tumor and the degree of differentiation is the most significant factor affecting prognosis and survival. An adequate systemic treatment is required in the case of poorly differentiated tumors. Neck dissection (ND) exerts a positive effect on the locoregional control of buccal SCC staged as cT1-2N0. In the case of identification of positive lymph nodes during surgery, postoperative radiation is recommended in order to improve locoregional control.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the buccal mucosa: Analysis of clinical presentation, outcome and prognostic factors

Fang

Shi

et al. 2013

Molecular and Clinical Oncology

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“…GSCC has a high risk of metastasis and consequent death with bone invasion of high-grade tumors (2). Recent advances in chemo, radiation, and surgical therapies offer near-complete recovery for patients with oral malignancies.…”

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confidence: 99%

Methylsulfonylmethane Induces G1 Arrest and Mitochondrial Apoptosis in YD-38 Gingival Cancer Cells

2017

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“…Moreover, our results showed an uneven higher rate of developing metastatic disease if tumors involved the buccal alveolar mucosa. Similarly, carcinomas of the maxillary gingival-buccal complex are reported to have an aggressive metastatic behavior [37]. One congruent observation was made by Zhang et al who reported a significantly increased rate of 70% of initially confirmed cervical metastases of tumors expanding in the upper vestibular fold (p \ 0.01) [22].…”

Section: Discussionmentioning

confidence: 89%

Metastatic pattern in squamous cell carcinoma of the hard palate and maxillary alveolar ridge: clinical experience and review of the literature

et al. 2017

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Purpose Oral squamous cell carcinoma of the hard palate and upper alveolar ridge is rare with only few published current data regarding regional metastases after elective neck dissection or adjuvant therapy. Our aim was to investigate the incidence of initial and delayed nodal metastasis and to identify predictive factors. Methods In a retrospective cohort study, we enrolled 48 primarily surgical-treated patients from 2004 to 2014. Results Pathological initial nodal metastasis rate was 13.3% (6/45). Poor histologic grade (p = 0.048), lymphovascular infiltration (p \ 0.001) and perineural infiltration (p = 0.01) correlated with initial nodal metastasis, while advanced T-stage showed no significance (p = 0.07). Regional recurrences occurred in 14.6% of patients (7/48) and tended to emerge less frequently after therapeutic than elective neck dissection. Tumor involvement of the vestibular alveolar mucosa was a prognostic factor for developing regional recurrence (p = 0.034). Overall nodal disease rate was 27.1% (13/48). Disease-free and overall survival rates were at 73 and 93%, respectively. Conclusions The presence of poor histologic characteristics is a high risk for nodal metastasis. In patients with tumors in contact with the upper vestibular fold, the hypothesis of an impact on metastasis needs further validation.

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Squamous cell carcinoma of the superior gingival–buccal complex

Cited by 32 publications

References 5 publications

Squamous cell carcinoma of the buccal mucosa: Analysis of clinical presentation, outcome and prognostic factors

Squamous cell carcinoma of the buccal mucosa: Analysis of clinical presentation, outcome and prognostic factors

Methylsulfonylmethane Induces G1 Arrest and Mitochondrial Apoptosis in YD-38 Gingival Cancer Cells

Metastatic pattern in squamous cell carcinoma of the hard palate and maxillary alveolar ridge: clinical experience and review of the literature

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