Squamous Cell Carcinoma of the Head and Neck in Ontario, Canada, and in Southeastern Norway

Hall, Stephen F.; Boysen, Morten; Groome, Patti A.; Mackillop, William J.

doi:10.1097/00005537-200304000-00021

Cited by 9 publications

(14 citation statements)

References 27 publications

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“…The overall survival at 5 years was 26% and the authors chose to report disease‐free survival not disease‐specific survival as their major outcome. Their TNM stage case mix appears to be more severe than both our series and the Hoffman survey and could reflect true differences, stage migration, different staging rules, different investigations or the poor reliability of TNM 20 …”

Section: Discussioncontrasting

confidence: 57%

“…Their TNM stage case mix appears to be more severe than both our series and the Hoffman survey and could reflect true differences, stage migration, different staging rules, different investigations or the poor reliability of TNM. 20 Eckel et al 6 reported a series of 228 consecutive cases treated a single institution in Germany. The mean age was 53, which is much younger than other series.…”

Section: Comparisons With the Literaturementioning

confidence: 99%

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The Natural History of Patients With Squamous Cell Carcinoma of the Hypopharynx

et al. 2008

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Section: Discussioncontrasting

confidence: 57%

Section: Comparisons With the Literaturementioning

confidence: 99%

The Natural History of Patients With Squamous Cell Carcinoma of the Hypopharynx

et al. 2008

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“…Likewise, treatment was withheld when patients were considered mentally unfit for treatment. The percentage of patients excluded (7.9%) from treatment in this study is similar to that previously reported from a comparable institution in Canada [7]. As life expectancy increases, clinicians increasingly face the challenge of treating elderly patients with cancer, including some types of head and neck carcinomas [8].…”

Section: Discussionsupporting

confidence: 81%

Squamous Cell Carcinoma of the Head and Neck in the Elderly

Boysen¹

2009

TOOTORJ

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Background: Increasing life expectancy and incidence of head and neck carcinomas, including some types of head and neck malignancies, lead to a constantly higher proportion of old oncologic patients. Previous reports regarding the outcome for elderly patients with head and neck carcinomas squamous cell carcinoma (HNSCC) are controversial. For further insight, a large single-institution material has been analysed. Material: Prospective recording of demographic details, continuous follow-up and determining exact cause of deaths of patients with carcinoma of the head and neck have been in progress over a period of 14 years. Having excluded 154 patients (7.3%), who did not follow-up, who had distant metastases at diagnosis, or who had received extensive treatment for a previous head and neck carcinoma or who refused treatment, or for medical or mental reasons, were unable to receive curative treatments. The material includes 1944 patients, of whom 37% received combined treatment, 58% radiotherapy alone and 6% surgery alone. The mean age was 65 years with a mean follow-up of 3.8 years. The material was divided into two groups; 65 and >65 years of age and analysed by means of X 2 tests and log-rank X 2 tests. Results: Early stage primary tumours and a more advantageous N-classification were more conspicuous among the older patients (p = 0.2406 and p<0.0002). The group of patients 65 years had a significantly better disease-specific survival rate compared to the older patients (p = 0.145). However, 40 % of the older patients were alive with no evidence of disease. By comparing 65-74 patients with patients' 76 years of age, a p-value of 0.0105 was obtained in favour of the younger group, but still an appreciable number of the older patients escaped their HNSCC. Conclusion: Given a satisfactory mental and physical condition, patients older than 65 years had a reasonable disease-specific survival. It is therefore no reason to withhold appropriate treatment for the elderly, fit patients which could prevent or delay the misery and devastating situation, as well as a reduction in the heavy expenditures that patients with persistent or recurrent head and neck tumours represent.

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“…The information is entered by a records technologist into the Head & Neck file of the MEDLOG Clinical Database System [10]. The information in this prospective database has been the data source for numerous publications [11][12][13][14][15], and for this study provides an opportunity for a unique audit of the data elements within the OCR that are important to researchers in clinical oncology.…”

Section: Introductionmentioning

confidence: 99%