Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets

Hong, Angela; Grulich, Andrew E.; Jones, D. Brian; Lee, C. Soon; Garland, Suzanne M.; Dobbins, Timothy; Clark, Jonathan R.; Harnett, Gerald B.; Milross, Christopher G.; O’Brien, Christopher J.; Rose, Barbara

doi:10.1016/j.vaccine.2010.02.098

Cited by 131 publications

(103 citation statements)

References 24 publications

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“…HPV-driven HNSCCs have been increasing in recent decades [8,20], so it is surprising that little is known about the fundamental dynamics of oral HPV infection, including basic epidemiological constructs such as the prevalence of infection, the incidence of new infections and the rate of clearance of existing infections. Such knowledge about the natural history of oral HPV infection would help to better understand the likely trajectory of HPV-driven HNSCCs in the future.…”

Section: Discussionmentioning

confidence: 99%

Oral human papillomavirus infection incidence and clearance: a systematic review of the literature

Wood

Bain

Smith

et al. 2017

Journal of General Virology

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Subclinical oral human papillomavirus (HPV) infection that persists for decades is likely to precede an HPV-driven squamous cell carcinoma of the head and neck, but little is known about the natural history of oral HPV. We systematically reviewed and abstracted data from nine manuscripts that examined human immunodeficiency virusnegative and cancer-free subjects for oral HPV DNA to determine the pooled baseline prevalence and incidence of newly acquired oral HPV infections, and specifically for HPV-16. We also documented the clearance rate and the median time to clearance, where data existed. Of 3762 individuals, 7.5 % had an oral infection with any HPV type (1.6 % for HPV-16). Meta-regression analysis estimated the 12-month cumulative incidence to be 4.8 % (95 % confidence interval 3.2-7.3 %). The overall oral HPV clearance was reported to be 0-80 % between studies, and the median time to clearance from 6.5 to 18 months. Oral HPV-16 clearance was 43-83 %, and median time to clearance for HPV-16 was 7-22 months. Oral HPV prevalence, incidence and clearance vary considerably between published studies from different geographical regions. Further research is required to identify predictors of persistent oral HPV infection. Measurable baseline prevalence was observed in all studies, as well as non-trivial incidence of newly acquired oral HPV infections and incomplete clearance.

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Section: Discussionmentioning

confidence: 99%

Oral human papillomavirus infection incidence and clearance: a systematic review of the literature

Wood

Bain

Smith

et al. 2017

Journal of General Virology

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“…Notably, these increases have occurred despite declines in the prevalence of cigarette smoking, an important oropharyngeal cancer risk factor (1,5). Changes in sexual behaviors through the sexual revolution and increased oral/oropharyngeal human papillomavirus (HPV) exposure are believed to have contributed to the rising oropharyngeal cancer incidence among cohorts born during and after the 1940s (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Tonsillectomy and Incidence of Oropharyngeal Cancers

Chaturvedi

Song

Rosenberg

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Rising incidence of oropharyngeal cancers in numerous countries since the 1970s has been attributed to increased oral human papillomavirus (HPV) exposure. However, the contribution of coincidental declines in the surgical removal of the tonsils (tonsillectomy) is unknown. We quantified the association of tonsillectomy with risk of tonsillar, other oropharyngeal, and other head and neck cancers and the contribution of declines in tonsillectomies to cancer incidence trends.Methods: We conducted a nation-wide cohort study in Sweden (1970Sweden ( -2009. Tonsillectomies (N ¼ 225,718) were identified through national patient registers, which were linked with the cancer register. Cancer incidence in the tonsillectomy cohort was compared with Sweden's general population through standardized incidence ratios (SIR).Results: Tonsillectomies were associated with reduced risk of tonsil cancers [SIRs 1þ years post-tonsillectomy ¼ 0.31; 95% confidence interval (CI), 0.08-0.79 and 5þ years post-tonsillectomy ¼ 0.17; 95% CI, 0.02-0.62], but unrelated to other oro-

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“…2,[15][16][17][18] This is attributable to a rising incidence of HPV positive OSCC with up to 70% of OSCC caused by HPV and type 16 accounting for more than 90% of the cases. 14 The oncogenicity of HPV is directly related to the expression of E6 and E7.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 More than 90% of HPV positive OSCC is caused by the HPV type 16 genotype. 3 The prognostic significance of HPV in OSCC is well established, with HPV positive OSCC having significantly better outcomes after adjusting for other known prognostic variables.…”

Section: Introductionmentioning

confidence: 99%

E6 viral protein ratio correlates with outcomes in human papillomavirus related oropharyngeal cancer

Hong

Zhang

Jones

et al. 2015

Cancer Biology & Therapy

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Background: The study aimed to identify prognostic markers to improve the management of patients with HPV positive OSCC Methods: We determined the ratio of HPV E6*I and E6*II splice variants by quantitative RT-PCR in 177 HPV positive OSCC and correlated the findings with other clinicopathological data Results: There was no significant difference in locoregional recurrence (HR 1.72 p D 0.24) and death (HR 1.65, p D 0.13) among patients whose tumors had an E6*I/*II ratio 1 compared with an E6*I/*II ratio of <1. Univariate analysis showed that patients with E6*I/*II 1 OSCC were more likely to have an event. In the multivariable analysis, there was a trend for more events in patients with E6*I/*II ratio 1 (HR 1.70, 95% CI 0.95-3.03, p D 0.07) Conclusion: Our data suggest that the use of HPV 16 spliced transcripts may help to predict for poorer outcomes in patients with HPV positive OSCC.

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Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets

Cited by 131 publications

References 24 publications

Oral human papillomavirus infection incidence and clearance: a systematic review of the literature

Oral human papillomavirus infection incidence and clearance: a systematic review of the literature

Tonsillectomy and Incidence of Oropharyngeal Cancers

E6 viral protein ratio correlates with outcomes in human papillomavirus related oropharyngeal cancer

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